The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients
Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of β-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effec...
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Published in | Indian heart journal Vol. 70; no. 5; pp. 608 - 614 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.09.2018
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Abstract | Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of β-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in animal model. This study aims to prove the effect of PsP as potent antioxidant in high risk and stable angina patients.
This is a clinical trial conducted to 37 high risk and 34 stable angina patients, which were determined based on ESC Stable CAD Guidelines and Framingham risk score, with pre and post test design without control group. The parameters are superoxide dimustase (SOD) and malondialdehyde (MDA) concentration, circulating endothelial cell (CEC) and endothelial progenitor cell (EPC) counts. The patients were given PsP 750mg/day in 3 divided dose for 90days. Paired t-test was performed for normally distributed data, and Wilcoxon test for not normally distributed data, and significant level of p≤0,05.
SOD level in high risk patients slightly increased but not statistically significant with p=0,22. Level of SOD in stable angina group significantly increased with p=0,001. MDA concentration significantly reduced in high risk and stable angina patients with p=0.000. CEC significantly reduced both in high risk and stable angina patients, with p=0.000 in both groups. EPC count significantly reduced in high risk and stable angina with p=0.000.
PsP of Ganoderma lucidum is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients |
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AbstractList | Objectives: Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of β-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in animal model. This study aims to prove the effect of PsP as potent antioxidant in high risk and stable angina patients. Method: This is a clinical trial conducted to 37 high risk and 34 stable angina patients, which were determined based on ESC Stable CAD Guidelines and Framingham risk score, with pre and post test design without control group. The parameters are superoxide dimustase (SOD) and malondialdehyde (MDA) concentration, circulating endothelial cell (CEC) and endothelial progenitor cell (EPC) counts. The patients were given PsP 750 mg/day in 3 divided dose for 90 days. Paired t-test was performed for normally distributed data, and Wilcoxon test for not normally distributed data, and significant level of p ≤ 0,05. Results: SOD level in high risk patients slightly increased but not statistically significant with p = 0,22. Level of SOD in stable angina group significantly increased with p = 0,001. MDA concentration significantly reduced in high risk and stable angina patients with p = 0.000. CEC significantly reduced both in high risk and stable angina patients, with p = 0.000 in both groups. EPC count significantly reduced in high risk and stable angina with p = 0.000. Conclusion: PsP of Ganoderma lucidum is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients Keywords: Polysaccharide peptide, Ganoderma lucidum, Antioxidant, Stable angina, High risk patients Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of β-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in animal model. This study aims to prove the effect of PsP as potent antioxidant in high risk and stable angina patients. This is a clinical trial conducted to 37 high risk and 34 stable angina patients, which were determined based on ESC Stable CAD Guidelines and Framingham risk score, with pre and post test design without control group. The parameters are superoxide dimustase (SOD) and malondialdehyde (MDA) concentration, circulating endothelial cell (CEC) and endothelial progenitor cell (EPC) counts. The patients were given PsP 750mg/day in 3 divided dose for 90days. Paired t-test was performed for normally distributed data, and Wilcoxon test for not normally distributed data, and significant level of p≤0,05. SOD level in high risk patients slightly increased but not statistically significant with p=0,22. Level of SOD in stable angina group significantly increased with p=0,001. MDA concentration significantly reduced in high risk and stable angina patients with p=0.000. CEC significantly reduced both in high risk and stable angina patients, with p=0.000 in both groups. EPC count significantly reduced in high risk and stable angina with p=0.000. PsP of Ganoderma lucidum is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide (PsP) derived from Ganoderma lucidum has an active substance in the form of β-glucan. Previous studies have proven the PsP of Ganoderma lucidum as an effective antioxidant in atherosclerotic rats and shows no toxicity in animal model. This study aims to prove the effect of PsP as potent antioxidant in high risk and stable angina patients. This is a clinical trial conducted to 37 high risk and 34 stable angina patients, which were determined based on ESC Stable CAD Guidelines and Framingham risk score, with pre and post test design without control group. The parameters are superoxide dimustase (SOD) and malondialdehyde (MDA) concentration, circulating endothelial cell (CEC) and endothelial progenitor cell (EPC) counts. The patients were given PsP 750mg/day in 3 divided dose for 90days. Paired t-test was performed for normally distributed data, and Wilcoxon test for not normally distributed data, and significant level of p≤0,05. SOD level in high risk patients slightly increased but not statistically significant with p=0,22. Level of SOD in stable angina group significantly increased with p=0,001. MDA concentration significantly reduced in high risk and stable angina patients with p=0.000. CEC significantly reduced both in high risk and stable angina patients, with p=0.000 in both groups. EPC count significantly reduced in high risk and stable angina with p=0.000. PsP of Ganoderma lucidum is a potent antioxidant against pathogenesis of atherosclerosis in stable angina and high risk patients. |
Author | Vitriyaturrida Siwi Proboretno, Kartika Sargowo, Djanggan Susilowati, Eliana Ubaidillah, Nizamuddin Ramadhan, Fadhli Waranugraha, Yoga Ovianti, Nadia Failasufi, Mirza Widya Nugraha, Adriyawan Hayuning Putri, Dinarsari Wulandari, Hesti |
AuthorAffiliation | a Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia b Master Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia |
AuthorAffiliation_xml | – name: b Master Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia – name: a Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia |
Author_xml | – sequence: 1 givenname: Djanggan surname: Sargowo fullname: Sargowo, Djanggan organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 2 givenname: Nadia surname: Ovianti fullname: Ovianti, Nadia email: nadia.iviight@gmail.com organization: Master Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia – sequence: 3 givenname: Eliana surname: Susilowati fullname: Susilowati, Eliana organization: Master Program of Biomedical Science, Faculty of Medicine, Brawijaya University, Malang, Indonesia – sequence: 4 givenname: Nizamuddin surname: Ubaidillah fullname: Ubaidillah, Nizamuddin organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 5 givenname: Adriyawan surname: Widya Nugraha fullname: Widya Nugraha, Adriyawan organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 6 surname: Vitriyaturrida fullname: Vitriyaturrida organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 7 givenname: Kartika surname: Siwi Proboretno fullname: Siwi Proboretno, Kartika organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 8 givenname: Mirza surname: Failasufi fullname: Failasufi, Mirza organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 9 givenname: Fadhli surname: Ramadhan fullname: Ramadhan, Fadhli organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 10 givenname: Hesti surname: Wulandari fullname: Wulandari, Hesti organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 11 givenname: Yoga surname: Waranugraha fullname: Waranugraha, Yoga organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia – sequence: 12 givenname: Dinarsari surname: Hayuning Putri fullname: Hayuning Putri, Dinarsari organization: Department of Cardiology and Vascular Medicine, Faculty of Medicine, Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia |
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Keywords | CEC NO Ganoderma lucidum VEGF Stable angina SOD MDA PsP Antioxidant SDF LDL EPC HSC Polysaccharide peptide CVCU High risk patients |
Language | English |
License | This is an open access article under the CC BY-NC-ND license. Copyright © 2017 Cardiological Society of India. Published by Elsevier B.V. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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Snippet | Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide (PsP) derived... Objectives: Antioxidants can reduce oxidative radicals that affect the early phase of atherogenesis, that is endothelial dysfunction. Polysaccharide Peptide... |
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SubjectTerms | Angina, Stable - blood Angina, Stable - prevention & control Antioxidant Antioxidants - administration & dosage Atherosclerosis - blood Atherosclerosis - prevention & control Clinical and Preventive Cardiology Dose-Response Relationship, Drug Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Free Radical Scavengers - blood Ganoderma lucidum High risk patients Humans Plant Extracts - administration & dosage Polysaccharide peptide Proteoglycans - administration & dosage Reishi Risk Factors Single-Blind Method Stable angina Treatment Outcome Vasodilation - drug effects |
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Title | The role of polysaccharide peptide of Ganoderma lucidum as a potent antioxidant against atherosclerosis in high risk and stable angina patients |
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