Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungs

• Published in: Scientific reports Vol. 11; no. 1; p. 18607
• Main Authors: Carstens, Henning, Kalka, Katharina, Verhaegh, Rabea, Schumacher, Fabian, Soddemann, Matthias, Wilker, Barbara, Keitsch, Simone, Sehl, Carolin, Kleuser, Burkhard, Wahlers, Thorsten, Reiner, Gerald, Koch, Achim, Rauen, Ursula, Gulbins, Erich, Kamler, Markus
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/1438; 631/154/152; 692/699/255; Antibiotics; Bronchopulmonary infection; Bronchus; Ceramide; Corticoids; Corticosteroids; E coli; Epithelial cells; Humanities and Social Sciences; Inhalation; Lung transplantation; Lungs; multidisciplinary; Paraffin; Perfusion; Respiratory tract; Science; Science (multidisciplinary); Side effects; Trachea; Ventilation

Ex-vivo lung perfusion (EVLP) systems like XVIVO are more and more common in the setting of lung transplantation, since marginal donor-lungs can easily be subjected to a performance test or be treated with corticosteroids or antibiotics in high dose regimes. Donor lungs are frequently positive in br...