CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation

• Published in: Breast cancer research : BCR Vol. 27; no. 1; pp. 81 - 22
• Main Authors: Carlson, Eric G., Lopez, Jennifer C., Yamaguchi, Yukiko, Gibson, Jackson, Priceman, Saul J., LaBarge, Mark A.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.05.2025; BioMed Central; BMC
• Subjects: Adipogenesis; Adolescent; Adult; Aged; Aging; Antibodies; BRCA1; BRCA1 protein; BRCA1 Protein - genetics; Breast cancer; Breast Neoplasms - etiology; Breast Neoplasms - genetics; Breast Neoplasms - immunology; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; Cancer-Associated Fibroblasts - immunology; Cancer-Associated Fibroblasts - metabolism; Cancer-Associated Fibroblasts - pathology; CD105 antigen; Cell proliferation; Coculture Techniques; Disease susceptibility; Endoglin - metabolism; Epithelial cells; Ethylenediaminetetraacetic acid; Female; Fibroblasts; Fibroblasts - immunology; Fibroblasts - metabolism; Health aspects; Human subjects; Humans; Immune system; Immunosuppressive; Immunosurveillance; Inflammation; Intralobular fibroblasts; Lymphocytes T; Macrophages; Macrophages - immunology; Macrophages - metabolism; Mammary gland; Middle Aged; Mutation; Polarization; Review boards; Risk factors; Stroma; Tumor Microenvironment - immunology; Young Adult; Aging; Immunosuppressive; Intralobular fibroblasts; BRCA1; Macrophages

Aging is the greatest risk factor for breast cancer, and although epithelial cells are the source of carcinomas, epithelial changes alone do not fully explain cancer susceptibility. Fibroblasts and macrophages are key stromal constituents around the cells of origin for cancer in breast tissue. With...