α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

• Published in: Nature communications Vol. 12; no. 1; pp. 4113 - 16
• Main Authors: Xie, Xuan, Wang, Shaogang, Li, Mingyi, Diao, Lei, Pan, Xingyu, Chen, Jijun, Zou, Weiguo, Zhang, Xu, Feng, Wenfeng, Bao, Lan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.07.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/51; 14/19; 14/28; 14/34; 14/63; 631/378/2571; 631/80/128/1653; 82/80; 82/83; Acetylation; Antibodies; Axons; Brain research; Cell migration; Cerebral cortex; Cytokinesis; Cytoplasm; Embryos; Humanities and Social Sciences; Laboratories; Lysine; Methylation; Methyltransferase; Microtubules; Mimicry; Mitosis; Morphology; multidisciplinary; Neurons; Nucleation; Paclitaxel; Peptides; Polarization; Post-translation; Science; Science (multidisciplinary); Stem cells; Translation; Tubulin

Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is re...