α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is re...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 12; no. 1; pp. 4113 - 16
Main Authors Xie, Xuan, Wang, Shaogang, Li, Mingyi, Diao, Lei, Pan, Xingyu, Chen, Jijun, Zou, Weiguo, Zhang, Xu, Feng, Wenfeng, Bao, Lan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 05.07.2021
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/51
14/19
14/28
14/34
14/63
631/378/2571
631/80/128/1653
82/80
82/83
Acetylation
Antibodies
Axons
Brain research
Cell migration
Cerebral cortex
Cytokinesis
Cytoplasm
Embryos
Humanities and Social Sciences
Laboratories
Lysine
Methylation
Methyltransferase
Microtubules
Mimicry
Mitosis
Morphology
multidisciplinary
Neurons
Nucleation
Paclitaxel
Peptides
Polarization
Post-translation
Science
Science (multidisciplinary)
Stem cells
Translation
Tubulin
Online AccessGet full text

Cover

Abstract Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. α-TubK40me3 is enriched in mouse cerebral cortex during embryonic day (E)14 to E16. Knockdown of α-tubulin methyltransferase SETD2 at E14 leads to the defects in neuronal migration, which could be restored by overexpressing either a cytoplasm-localized SETD2 truncation or α-TubK40me3-mimicking mutant. Furthermore, α-TubK40me3 is preferably distributed on polymerized microtubules and potently promotes tubulin nucleation. Downregulation of α-TubK40me3 results in reduced microtubule abundance in neurites and disrupts neuronal polarization, which could be rescued by Taxol. Additionally, α-TubK40me3 is increased after losing α-tubulin K40 acetylation (α-TubK40ac) and largely rescues α-TubK40ac function. This study reveals a critical role of α-TubK40me3 in microtubule formation and neuronal development. Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.
AbstractList Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. α-TubK40me3 is enriched in mouse cerebral cortex during embryonic day (E)14 to E16. Knockdown of α-tubulin methyltransferase SETD2 at E14 leads to the defects in neuronal migration, which could be restored by overexpressing either a cytoplasm-localized SETD2 truncation or α-TubK40me3-mimicking mutant. Furthermore, α-TubK40me3 is preferably distributed on polymerized microtubules and potently promotes tubulin nucleation. Downregulation of α-TubK40me3 results in reduced microtubule abundance in neurites and disrupts neuronal polarization, which could be rescued by Taxol. Additionally, α-TubK40me3 is increased after losing α-tubulin K40 acetylation (α-TubK40ac) and largely rescues α-TubK40ac function. This study reveals a critical role of α-TubK40me3 in microtubule formation and neuronal development.Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.
Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. α-TubK40me3 is enriched in mouse cerebral cortex during embryonic day (E)14 to E16. Knockdown of α-tubulin methyltransferase SETD2 at E14 leads to the defects in neuronal migration, which could be restored by overexpressing either a cytoplasm-localized SETD2 truncation or α-TubK40me3-mimicking mutant. Furthermore, α-TubK40me3 is preferably distributed on polymerized microtubules and potently promotes tubulin nucleation. Downregulation of α-TubK40me3 results in reduced microtubule abundance in neurites and disrupts neuronal polarization, which could be rescued by Taxol. Additionally, α-TubK40me3 is increased after losing α-tubulin K40 acetylation (α-TubK40ac) and largely rescues α-TubK40ac function. This study reveals a critical role of α-TubK40me3 in microtubule formation and neuronal development.
Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. α-TubK40me3 is enriched in mouse cerebral cortex during embryonic day (E)14 to E16. Knockdown of α-tubulin methyltransferase SETD2 at E14 leads to the defects in neuronal migration, which could be restored by overexpressing either a cytoplasm-localized SETD2 truncation or α-TubK40me3-mimicking mutant. Furthermore, α-TubK40me3 is preferably distributed on polymerized microtubules and potently promotes tubulin nucleation. Downregulation of α-TubK40me3 results in reduced microtubule abundance in neurites and disrupts neuronal polarization, which could be rescued by Taxol. Additionally, α-TubK40me3 is increased after losing α-tubulin K40 acetylation (α-TubK40ac) and largely rescues α-TubK40ac function. This study reveals a critical role of α-TubK40me3 in microtubule formation and neuronal development. Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.
Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.
Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. α-TubK40me3 is enriched in mouse cerebral cortex during embryonic day (E)14 to E16. Knockdown of α-tubulin methyltransferase SETD2 at E14 leads to the defects in neuronal migration, which could be restored by overexpressing either a cytoplasm-localized SETD2 truncation or α-TubK40me3-mimicking mutant. Furthermore, α-TubK40me3 is preferably distributed on polymerized microtubules and potently promotes tubulin nucleation. Downregulation of α-TubK40me3 results in reduced microtubule abundance in neurites and disrupts neuronal polarization, which could be rescued by Taxol. Additionally, α-TubK40me3 is increased after losing α-tubulin K40 acetylation (α-TubK40ac) and largely rescues α-TubK40ac function. This study reveals a critical role of α-TubK40me3 in microtubule formation and neuronal development.Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule function and post-mitotic cells remains largely incomplete. Here, we report that α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation. α-TubK40me3 is enriched in mouse cerebral cortex during embryonic day (E)14 to E16. Knockdown of α-tubulin methyltransferase SETD2 at E14 leads to the defects in neuronal migration, which could be restored by overexpressing either a cytoplasm-localized SETD2 truncation or α-TubK40me3-mimicking mutant. Furthermore, α-TubK40me3 is preferably distributed on polymerized microtubules and potently promotes tubulin nucleation. Downregulation of α-TubK40me3 results in reduced microtubule abundance in neurites and disrupts neuronal polarization, which could be rescued by Taxol. Additionally, α-TubK40me3 is increased after losing α-tubulin K40 acetylation (α-TubK40ac) and largely rescues α-TubK40ac function. This study reveals a critical role of α-TubK40me3 in microtubule formation and neuronal development.
ArticleNumber 4113
Author Chen, Jijun
Diao, Lei
Pan, Xingyu
Feng, Wenfeng
Zhang, Xu
Xie, Xuan
Wang, Shaogang
Bao, Lan
Li, Mingyi
Zou, Weiguo
Author_xml – sequence: 1
  givenname: Xuan
  orcidid: 0000-0001-8160-7493
  surname: Xie
  fullname: Xie, Xuan
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
– sequence: 2
  givenname: Shaogang
  orcidid: 0000-0001-8323-4301
  surname: Wang
  fullname: Wang, Shaogang
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, School of Life Science and Technology, ShanghaiTech University
– sequence: 3
  givenname: Mingyi
  surname: Li
  fullname: Li, Mingyi
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
– sequence: 4
  givenname: Lei
  orcidid: 0000-0002-8176-2781
  surname: Diao
  fullname: Diao, Lei
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
– sequence: 5
  givenname: Xingyu
  surname: Pan
  fullname: Pan, Xingyu
  organization: Shanghai Research Center for Brain Science and Brain-Inspired Intelligence
– sequence: 6
  givenname: Jijun
  surname: Chen
  fullname: Chen, Jijun
  organization: Shanghai Research Center for Brain Science and Brain-Inspired Intelligence
– sequence: 7
  givenname: Weiguo
  orcidid: 0000-0003-2516-0302
  surname: Zou
  fullname: Zou, Weiguo
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences
– sequence: 8
  givenname: Xu
  surname: Zhang
  fullname: Zhang, Xu
  organization: University of Chinese Academy of Sciences, School of Life Science and Technology, ShanghaiTech University, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Laboratory of Perceptive Network, Shanghai Advanced Research Institute, Chinese Academy of Sciences
– sequence: 9
  givenname: Wenfeng
  orcidid: 0000-0003-3475-8461
  surname: Feng
  fullname: Feng, Wenfeng
  email: fengwenfeng@sibcb.ac.cn
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence
– sequence: 10
  givenname: Lan
  orcidid: 0000-0001-9269-9565
  surname: Bao
  fullname: Bao, Lan
  email: baolan@sibcb.ac.cn
  organization: State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, School of Life Science and Technology, ShanghaiTech University
BookMark eNp9ks1u1DAUhSNUREvpC7CKxIZNwP92Nkio4qeiEpvZW459PXiU2FM7QWrfihfhmfBMKqBd1Bvb1985vrLPy-YkpghN8xqjdxhR9b4wzITsEMEdYVSKjjxrzghiuMOS0JP_1qfNRSk7VAftsWLsRXNKGSGCM3TW2N-_us0yfGNoAtqG0ma4WUIG1_qU2whLTtGM7T6NJoc7M4cUWxNdO4VtXnfDbbvPaUpziNtatjnNy7CMcDCYjsir5rk3Y4GL-_m82Xz-tLn82l1__3J1-fG6sxzLuQPGeqOEUASoktiCU9xC7wWSRHrusR960jvpwUmhhJSYGuOU48YJ5Sk9b65WW5fMTu9zmEy-1ckEfSykvNUmz8GOoAXGQAZjPJWKeUoMp30_OG4FCK-MqF4fVq_9MkzgLMQ5m_GB6cOTGH7obfqpFeGSy4PB23uDnG4WKLOeQrEwjiZCWoomnKkeE0RRRd88QndpyfXVV4odQFUpslL1gUvJ4P82g5E-JEKvidA1EfqYCE2qSD0S2TAf_6Q2HcanpXSVlnpP3EL-19UTqj8rlc0v
CitedBy_id crossref_primary_10_1016_j_molstruc_2022_134169
crossref_primary_10_3390_genes14061179
crossref_primary_10_1016_j_celrep_2022_111693
crossref_primary_10_3389_fnins_2023_989109
crossref_primary_10_1038_s41467_024_52729_0
crossref_primary_10_1042_BST20240841
crossref_primary_10_1021_acschemneuro_2c00189
crossref_primary_10_3390_biology12040561
crossref_primary_10_1167_iovs_63_4_24
crossref_primary_10_3390_ijms24032781
crossref_primary_10_1093_genetics_iyae015
crossref_primary_10_1242_jcs_261406
crossref_primary_10_3390_biology13060424
crossref_primary_10_1016_j_brainres_2024_148847
crossref_primary_10_1002_dvg_23448
crossref_primary_10_1016_j_jtha_2024_03_010
crossref_primary_10_1016_j_bbrc_2022_05_040
crossref_primary_10_1091_mbc_E23_12_0492
crossref_primary_10_1093_oons_kvac007
Cites_doi 10.1016/j.cell.2006.12.021
10.1083/jcb.103.2.571
10.1016/S1046-5928(03)00218-3
10.1038/ncomms12187
10.1038/ncb3481
10.1371/journal.pone.0005405
10.15252/embj.2018100440
10.1083/jcb.200707042
10.1038/nrm3227
10.1016/j.tins.2006.05.006
10.1093/cercor/bhx104
10.1007/s00018-017-2517-x
10.1016/j.cell.2014.03.061
10.1016/j.cell.2016.07.005
10.1038/nrm1761
10.1016/j.neuron.2015.11.009
10.1126/science.aai8764
10.1101/cshperspect.a001834
10.1038/s41580-020-0214-3
10.1016/S0021-9258(19)68489-9
10.1007/s10803-015-2484-8
10.1242/dev.069963
10.1242/jcs.094672
10.1038/nrm.2017.75
10.1523/JNEUROSCI.0016-12.2012
10.1126/science.aao4165
10.1038/nrm.2016.162
10.1016/S0092-8674(00)80961-7
10.1073/pnas.0915033107
10.1038/nature11326
10.1074/jbc.M113.522839
10.3389/fgene.2019.01291
10.1016/j.tig.2009.10.003
10.1074/mcp.M600223-MCP200
10.1021/pr800375z
10.1016/j.neuron.2015.05.046
10.1038/sj.emboj.7601967
10.1016/j.cell.2015.07.012
10.1242/jcs.199471
ContentType Journal Article
Copyright The Author(s) 2021
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2021
– notice: The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-021-24376-2
DatabaseName Springer Nature OA Free Journals
CrossRef
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
PML(ProQuest Medical Library)
Biological Science Database
AAdvanced Technologies & Aerospace Database (subscription)
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList Publicly Available Content Database
CrossRef


MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 16
ExternalDocumentID oai_doaj_org_article_611e2baaf3784f32a5399bd5c6e6f8a6
PMC8257576
10_1038_s41467_021_24376_2
GrantInformation_xml – fundername: Strategic Priority Research Program of the Chinese Academy of Sciences (XDB19000000) Shanghai Science and Technology Committee (18JC1420301)
– fundername: National Natural Science Foundation of China (National Science Foundation of China)
  grantid: 31991194; 31330046
  funderid: https://doi.org/10.13039/501100001809
– fundername: ;
– fundername: ;
  grantid: 31991194; 31330046
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c517t-e449a86682e3871ced85ce9f60727f5f1fb929d7fed76867713aad8d5ad68f33
IEDL.DBID M48
ISSN 2041-1723
IngestDate Wed Aug 27 00:58:32 EDT 2025
Thu Aug 21 14:12:40 EDT 2025
Fri Jul 11 16:49:26 EDT 2025
Wed Aug 13 09:16:25 EDT 2025
Tue Jul 01 04:17:30 EDT 2025
Thu Apr 24 22:54:03 EDT 2025
Fri Feb 21 02:39:17 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c517t-e449a86682e3871ced85ce9f60727f5f1fb929d7fed76867713aad8d5ad68f33
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-8160-7493
0000-0003-2516-0302
0000-0002-8176-2781
0000-0001-8323-4301
0000-0003-3475-8461
0000-0001-9269-9565
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/s41467-021-24376-2
PMID 34226540
PQID 2548448918
PQPubID 546298
PageCount 16
ParticipantIDs doaj_primary_oai_doaj_org_article_611e2baaf3784f32a5399bd5c6e6f8a6
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8257576
proquest_miscellaneous_2548912030
proquest_journals_2548448918
crossref_primary_10_1038_s41467_021_24376_2
crossref_citationtrail_10_1038_s41467_021_24376_2
springer_journals_10_1038_s41467_021_24376_2
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2021-07-05
PublicationDateYYYYMMDD 2021-07-05
PublicationDate_xml – month: 07
  year: 2021
  text: 2021-07-05
  day: 05
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationYear 2021
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Witte, Neukirchen, Bradke (CR35) 2008; 180
Sánchez-Huertas (CR36) 2016; 7
Portran (CR24) 2017; 19
Gadadhar, Bodakuntla, Natarajan, Janke (CR3) 2017; 130
Janke, Bulinski (CR2) 2011; 12
Magiera (CR5) 2018; 37
Janke, Magiera (CR6) 2020; 21
Aillaud (CR16) 2017; 358
Wei (CR7) 2018; 28
Marin, Valiente, Ge, Tsai (CR12) 2010; 2
Martin, Zhang (CR29) 2005; 6
Edmunds, Mahadevan, Clayton (CR9) 2008; 27
Venkatesh (CR34) 2012; 489
Hu (CR10) 2010; 107
Lee, Davies, Mishima (CR18) 2012; 125
Kwan, Sestan, Anton (CR19) 2012; 139
Zhang, Alushin, Brown, Nogales (CR30) 2015; 162
Kapitein, Hoogenraad (CR1) 2015; 87
Li (CR15) 2012; 32
Nogales, Whittaker, Milligan, Downing (CR27) 1999; 96
Ayala, Shu, Tsai (CR11) 2007; 128
Zaghi, Broccoli, Sessa (CR33) 2020; 10
Roostalu, Surrey (CR25) 2017; 18
Castoldi, Popov (CR39) 2003; 32
D’Gama (CR31) 2015; 88
Jaglin, Chelly (CR14) 2009; 25
Maruta, Greer, Rosenbaum (CR38) 1986; 103
Lumish, Wynn, Devinsky, Chung (CR32) 2015; 45
Chung (CR21) 2014; 289
McDaniel, Strahl (CR20) 2017; 74
Xu (CR28) 2017; 356
Marcos (CR4) 2009; 4
Huq, Ha, Wei (CR23) 2008; 7
Hamel, Del Campo, Lowe, Lin (CR26) 1981; 256
Prosser, Pelletier (CR17) 2017; 18
Park (CR8) 2016; 166
Huq, Tsai, Khan, Wei (CR22) 2007; 6
LoTurco, Bai (CR13) 2006; 29
Szyk (CR37) 2014; 157
KY Kwan (24376_CR19) 2012; 139
IY Park (24376_CR8) 2016; 166
XH Jaglin (24376_CR14) 2009; 25
D Portran (24376_CR24) 2017; 19
S Marcos (24376_CR4) 2009; 4
S Gadadhar (24376_CR3) 2017; 130
L Li (24376_CR15) 2012; 32
H Witte (24376_CR35) 2008; 180
AM D’Gama (24376_CR31) 2015; 88
HS Lumish (24376_CR32) 2015; 45
M Hu (24376_CR10) 2010; 107
E Hamel (24376_CR26) 1981; 256
E Nogales (24376_CR27) 1999; 96
Z Xu (24376_CR28) 2017; 356
JJ LoTurco (24376_CR13) 2006; 29
C Aillaud (24376_CR16) 2017; 358
LC Kapitein (24376_CR1) 2015; 87
MM Magiera (24376_CR5) 2018; 37
D Wei (24376_CR7) 2018; 28
C Janke (24376_CR2) 2011; 12
SL Prosser (24376_CR17) 2017; 18
JW Edmunds (24376_CR9) 2008; 27
MD Huq (24376_CR23) 2008; 7
A Szyk (24376_CR37) 2014; 157
M Castoldi (24376_CR39) 2003; 32
C Sánchez-Huertas (24376_CR36) 2016; 7
HH Chung (24376_CR21) 2014; 289
KY Lee (24376_CR18) 2012; 125
R Zhang (24376_CR30) 2015; 162
SL McDaniel (24376_CR20) 2017; 74
M Zaghi (24376_CR33) 2020; 10
O Marin (24376_CR12) 2010; 2
MD Huq (24376_CR22) 2007; 6
H Maruta (24376_CR38) 1986; 103
R Ayala (24376_CR11) 2007; 128
S Venkatesh (24376_CR34) 2012; 489
C Martin (24376_CR29) 2005; 6
J Roostalu (24376_CR25) 2017; 18
C Janke (24376_CR6) 2020; 21
References_xml – volume: 128
  start-page: 29
  year: 2007
  end-page: 43
  ident: CR11
  article-title: Trekking across the brain: the journey of neuronal migration
  publication-title: Cell
  doi: 10.1016/j.cell.2006.12.021
– volume: 103
  start-page: 571
  year: 1986
  end-page: 579
  ident: CR38
  article-title: The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.103.2.571
– volume: 32
  start-page: 83
  year: 2003
  end-page: 88
  ident: CR39
  article-title: Purification of brain tubulin through two cycles of polymerization-depolymerization in a high-molarity buffer
  publication-title: Protein Expr. Purif.
  doi: 10.1016/S1046-5928(03)00218-3
– volume: 7
  year: 2016
  ident: CR36
  article-title: Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12187
– volume: 19
  start-page: 391
  year: 2017
  end-page: 398
  ident: CR24
  article-title: Tubulin acetylation protects long-lived microtubules against mechanical ageing
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3481
– volume: 4
  start-page: e5405
  year: 2009
  ident: CR4
  article-title: Tubulin tyrosination is required for the proper organization and pathfinding of the growth cone
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0005405
– volume: 37
  start-page: e100440
  year: 2018
  ident: CR5
  article-title: Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport
  publication-title: EMBO J.
  doi: 10.15252/embj.2018100440
– volume: 180
  start-page: 619
  year: 2008
  end-page: 632
  ident: CR35
  article-title: Microtubule stabilization specifies initial neuronal polarization
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200707042
– volume: 12
  start-page: 773
  year: 2011
  end-page: 786
  ident: CR2
  article-title: Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3227
– volume: 29
  start-page: 407
  year: 2006
  end-page: 413
  ident: CR13
  article-title: The multipolar stage and disruptions in neuronal migration
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2006.05.006
– volume: 28
  start-page: 3332
  year: 2018
  end-page: 3346
  ident: CR7
  article-title: α-Tubulin acetylation restricts axon overbranching by dampening microtubule plus-end dynamics in neurons
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhx104
– volume: 74
  start-page: 3317
  year: 2017
  end-page: 3334
  ident: CR20
  article-title: Shaping the cellular landscape with Set2/SETD2 methylation
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-017-2517-x
– volume: 157
  start-page: 1405
  year: 2014
  end-page: 1415
  ident: CR37
  article-title: Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase
  publication-title: Cell
  doi: 10.1016/j.cell.2014.03.061
– volume: 166
  start-page: 950
  year: 2016
  end-page: 962
  ident: CR8
  article-title: Dual chromatin and cytoskeletal remodeling by SETD2
  publication-title: Cell
  doi: 10.1016/j.cell.2016.07.005
– volume: 6
  start-page: 838
  year: 2005
  end-page: 849
  ident: CR29
  article-title: The diverse functions of histone lysine methylation
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1761
– volume: 88
  start-page: 910
  year: 2015
  end-page: 917
  ident: CR31
  article-title: Targeted DNA sequencing from autism spectrum disorder brains implicates multiple genetic mechanisms
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.11.009
– volume: 356
  start-page: 328
  year: 2017
  end-page: 332
  ident: CR28
  article-title: Microtubules acquire resistance from mechanical breakage through intralumenal acetylation
  publication-title: Science
  doi: 10.1126/science.aai8764
– volume: 2
  start-page: a001834
  year: 2010
  end-page: a001834
  ident: CR12
  article-title: Guiding neuronal cell migrations
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a001834
– volume: 21
  start-page: 307
  year: 2020
  end-page: 326
  ident: CR6
  article-title: The tubulin code and its role in controlling microtubule properties and functions
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-0214-3
– volume: 256
  start-page: 11887
  year: 1981
  end-page: 11894
  ident: CR26
  article-title: Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)68489-9
– volume: 45
  start-page: 3764
  year: 2015
  end-page: 3770
  ident: CR32
  article-title: Brief report: SETD2 mutation in a child with autism, intellectual disabilities and epilepsy
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-015-2484-8
– volume: 139
  start-page: 1535
  year: 2012
  end-page: 1546
  ident: CR19
  article-title: Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
  publication-title: Development
  doi: 10.1242/dev.069963
– volume: 125
  start-page: 3495
  year: 2012
  end-page: 3500
  ident: CR18
  article-title: Cytokinesis microtubule organisers at a glance
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.094672
– volume: 18
  start-page: 702
  year: 2017
  end-page: 710
  ident: CR25
  article-title: Microtubule nucleation: beyond the template
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2017.75
– volume: 32
  start-page: 12673
  year: 2012
  end-page: 12683
  ident: CR15
  article-title: MEC-17 deficiency leads to reduced alpha-tubulin acetylation and impaired migration of cortical neurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0016-12.2012
– volume: 358
  start-page: 1448
  year: 2017
  end-page: 1453
  ident: CR16
  article-title: Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation
  publication-title: Science
  doi: 10.1126/science.aao4165
– volume: 18
  start-page: 187
  year: 2017
  end-page: 201
  ident: CR17
  article-title: Mitotic spindle assembly in animal cells: a fine balancing act
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2016.162
– volume: 96
  start-page: 79
  year: 1999
  end-page: 88
  ident: CR27
  article-title: High-resolution model of the microtubule
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80961-7
– volume: 107
  start-page: 2956
  year: 2010
  end-page: 2961
  ident: CR10
  article-title: Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0915033107
– volume: 489
  start-page: 452
  year: 2012
  end-page: 455
  ident: CR34
  article-title: Set2 methylation of histone H3 lysine36 suppresses histone exchange on transcribed genes
  publication-title: Nature
  doi: 10.1038/nature11326
– volume: 289
  start-page: 5704
  year: 2014
  end-page: 5722
  ident: CR21
  article-title: Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.522839
– volume: 10
  start-page: 1291
  year: 2020
  ident: CR33
  article-title: H3K36 methylation in neural development and associated diseases
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.01291
– volume: 25
  start-page: 555
  year: 2009
  end-page: 566
  ident: CR14
  article-title: Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2009.10.003
– volume: 6
  start-page: 677
  year: 2007
  end-page: 688
  ident: CR22
  article-title: Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function
  publication-title: Mol. Cell Proteom.
  doi: 10.1074/mcp.M600223-MCP200
– volume: 7
  start-page: 4538
  year: 2008
  end-page: 4545
  ident: CR23
  article-title: Modulation of retinoic acid receptor alpha activity by lysine methylation in the DNA binding domain
  publication-title: J. Proteome Res.
  doi: 10.1021/pr800375z
– volume: 87
  start-page: 492
  year: 2015
  end-page: 506
  ident: CR1
  article-title: Building the neuronal microtubule cytoskeleton
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.05.046
– volume: 27
  start-page: 406
  year: 2008
  end-page: 420
  ident: CR9
  article-title: Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601967
– volume: 162
  start-page: 849
  year: 2015
  end-page: 859
  ident: CR30
  article-title: Mechanistic origin of microtubule dynamic instability and its modulation by EB proteins
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.012
– volume: 130
  start-page: 1347
  year: 2017
  end-page: 1353
  ident: CR3
  article-title: The tubulin code at a glance
  publication-title: J. Cell Sci.
– volume: 96
  start-page: 79
  year: 1999
  ident: 24376_CR27
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80961-7
– volume: 157
  start-page: 1405
  year: 2014
  ident: 24376_CR37
  publication-title: Cell
  doi: 10.1016/j.cell.2014.03.061
– volume: 12
  start-page: 773
  year: 2011
  ident: 24376_CR2
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3227
– volume: 21
  start-page: 307
  year: 2020
  ident: 24376_CR6
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-0214-3
– volume: 358
  start-page: 1448
  year: 2017
  ident: 24376_CR16
  publication-title: Science
  doi: 10.1126/science.aao4165
– volume: 103
  start-page: 571
  year: 1986
  ident: 24376_CR38
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.103.2.571
– volume: 25
  start-page: 555
  year: 2009
  ident: 24376_CR14
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2009.10.003
– volume: 18
  start-page: 187
  year: 2017
  ident: 24376_CR17
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2016.162
– volume: 125
  start-page: 3495
  year: 2012
  ident: 24376_CR18
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.094672
– volume: 4
  start-page: e5405
  year: 2009
  ident: 24376_CR4
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0005405
– volume: 6
  start-page: 838
  year: 2005
  ident: 24376_CR29
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1761
– volume: 45
  start-page: 3764
  year: 2015
  ident: 24376_CR32
  publication-title: J. Autism Dev. Disord.
  doi: 10.1007/s10803-015-2484-8
– volume: 32
  start-page: 12673
  year: 2012
  ident: 24376_CR15
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0016-12.2012
– volume: 356
  start-page: 328
  year: 2017
  ident: 24376_CR28
  publication-title: Science
  doi: 10.1126/science.aai8764
– volume: 139
  start-page: 1535
  year: 2012
  ident: 24376_CR19
  publication-title: Development
  doi: 10.1242/dev.069963
– volume: 10
  start-page: 1291
  year: 2020
  ident: 24376_CR33
  publication-title: Front. Genet.
  doi: 10.3389/fgene.2019.01291
– volume: 256
  start-page: 11887
  year: 1981
  ident: 24376_CR26
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(19)68489-9
– volume: 7
  year: 2016
  ident: 24376_CR36
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms12187
– volume: 7
  start-page: 4538
  year: 2008
  ident: 24376_CR23
  publication-title: J. Proteome Res.
  doi: 10.1021/pr800375z
– volume: 6
  start-page: 677
  year: 2007
  ident: 24376_CR22
  publication-title: Mol. Cell Proteom.
  doi: 10.1074/mcp.M600223-MCP200
– volume: 74
  start-page: 3317
  year: 2017
  ident: 24376_CR20
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-017-2517-x
– volume: 2
  start-page: a001834
  year: 2010
  ident: 24376_CR12
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a001834
– volume: 88
  start-page: 910
  year: 2015
  ident: 24376_CR31
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.11.009
– volume: 130
  start-page: 1347
  year: 2017
  ident: 24376_CR3
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.199471
– volume: 32
  start-page: 83
  year: 2003
  ident: 24376_CR39
  publication-title: Protein Expr. Purif.
  doi: 10.1016/S1046-5928(03)00218-3
– volume: 27
  start-page: 406
  year: 2008
  ident: 24376_CR9
  publication-title: EMBO J.
  doi: 10.1038/sj.emboj.7601967
– volume: 489
  start-page: 452
  year: 2012
  ident: 24376_CR34
  publication-title: Nature
  doi: 10.1038/nature11326
– volume: 87
  start-page: 492
  year: 2015
  ident: 24376_CR1
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.05.046
– volume: 29
  start-page: 407
  year: 2006
  ident: 24376_CR13
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2006.05.006
– volume: 19
  start-page: 391
  year: 2017
  ident: 24376_CR24
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3481
– volume: 128
  start-page: 29
  year: 2007
  ident: 24376_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2006.12.021
– volume: 37
  start-page: e100440
  year: 2018
  ident: 24376_CR5
  publication-title: EMBO J.
  doi: 10.15252/embj.2018100440
– volume: 289
  start-page: 5704
  year: 2014
  ident: 24376_CR21
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.522839
– volume: 107
  start-page: 2956
  year: 2010
  ident: 24376_CR10
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0915033107
– volume: 18
  start-page: 702
  year: 2017
  ident: 24376_CR25
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2017.75
– volume: 162
  start-page: 849
  year: 2015
  ident: 24376_CR30
  publication-title: Cell
  doi: 10.1016/j.cell.2015.07.012
– volume: 28
  start-page: 3332
  year: 2018
  ident: 24376_CR7
  publication-title: Cereb. Cortex
  doi: 10.1093/cercor/bhx104
– volume: 166
  start-page: 950
  year: 2016
  ident: 24376_CR8
  publication-title: Cell
  doi: 10.1016/j.cell.2016.07.005
– volume: 180
  start-page: 619
  year: 2008
  ident: 24376_CR35
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200707042
SSID ssj0000391844
Score 2.456402
Snippet Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However,...
Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational...
SourceID doaj
pubmedcentral
proquest
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 4113
SubjectTerms 13/1
13/51
14/19
14/28
14/34
14/63
631/378/2571
631/80/128/1653
82/80
82/83
Acetylation
Antibodies
Axons
Brain research
Cell migration
Cerebral cortex
Cytokinesis
Cytoplasm
Embryos
Humanities and Social Sciences
Laboratories
Lysine
Methylation
Methyltransferase
Microtubules
Mimicry
Mitosis
Morphology
multidisciplinary
Neurons
Nucleation
Paclitaxel
Peptides
Polarization
Post-translation
Science
Science (multidisciplinary)
Stem cells
Translation
Tubulin
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3LbtQwFL1ClSqxQZSHCC3ISOwg6vgZZwmoVQWC1SB1Z9mxXUZq01Fnsuhn8SN8U6_tzLSpRNmw9UNxro_te-zrY4D3sWXe40paC8ldLaKVOA8KW6dbkLYJzFOX9ju-_1AnP8XXU3l656mvFBNW5IGL4Q4VpYE5ayNvtIic2SSl6rzsVFBR2yy2jWveHTKV52DeInUR4y2ZGdeHK5HnhBSRkDT4VM0mK1EW7J94mfdjJO8dlOb15_gpPBkdR_KpNHgPHoX-GeyWpySvn0P353c9H9w3MbsInCxW5CqkGN_gCXqlJKtWpurLxGTHq5fE9p5cLM4KBoi7JssSm9efYTI2ej244TyQ7f3GFzA_Ppp_OanHBxTqTtJmXQchWquV0ixwJEZd8Fp2oY1qhl5LlJFGh96Rb2LwyDpUg4TVWq-9tF7pyPlL2Okv-_AKCFYSLmmrdZwL1siWC0epw-raUt_NKqAbW5puFBdPb1ycm3zIzbUp9jdof5Ptb1gFH7Z1lkVa48HSn1MXbUsmWeycgGAxI1jMv8BSwcGmg804VlcGKTJCRSNgKni3zcZRlo5ObB8uh1KmpQxnxAqaCTAmDZrm9ItfWa8bSXiDtK6CjxsI3X787z_8-n_88D48ZgnyaT9aHsDO-moIb9CLWru3ecDcANTDGjQ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Technology Collection
  dbid: 8FG
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3NjtMwELZgERIXxK8ILMhI3CDa-i9xTggQZQWCU5H2ZtmxXSrtpqVtDvtYvAjPxIzjZpWV2KvtUZzxeDwzHn9DyJvYcO_hJC2lEq6U0SrQg9KW-ArS1oF75jDe8f1HdfpTfj1TZzngtstplQedmBS1X7cYIz8BR0aDK9Ew_X7zu8SqUXi7mkto3CZ3GJw0mNKl51_GGAuinwNRfiszE_pkJ5NmwLwEROKrSj45jxJs_8TWvJ4pee26NJ1C8wfkfjYf6YdhvR-SW6F7RO4OBSUvH5P2759y0btvcnYRBF3t6DZgpm_wFGxTmrArkXyD_mx-gElt5-nFajlIAnWXdDNk6HVLaIZJ73vXnwc6vnJ8Qhbzz4tPp2Uuo1C2itX7MkjZWA3c4UGAe9QGr1UbmljNwHaJKrLowEbydQwefI-qBrfVWq-9sr7SUYin5Khbd-EZoUAkHSKstUJIXqtGSMeYA3JtmW9nBWEHXpo2Q4xjpYtzk666hTYD_w3w3yT-G16QtyPNZgDYuHH0R1yicSSCY6eG9XZp8l4zFWOBO2ujqLWMgltE33VetVWoorZVQY4PC2zyjt2ZK_kqyOuxG_YaXqDYLqz7YUzDOOjFgtQTwZhMaNrTrX4l1G5wxWtw7gry7iBCVx___w8_v3muL8g9jsKM8WZ1TI722z68BCtp716lrfAPZDwRRA
  priority: 102
  providerName: ProQuest
– databaseName: Springer Nature HAS Fully OA
  dbid: AAJSJ
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1La9wwEBYhIdBL6SvUbVpU6K01WT0tH7elIWxoL9lCbkKypO1C4l1214f8rP6R_KaM5EdxSAq5Shosj2ZGM9LMJ4Q-h5I6BztpzgWzOQ9GgB3kJo9VkKbw1BEbzzt-_pJnv_nsUlzuIdrXwqSk_QRpmcx0nx12suVJpWNCQYTQkzmY3YMI1Q6yfTCdzi5mw8lKxDxXnHcVMhOmHiAe7UIJrH_kYd7Pj7x3SZr2ntMX6HnnNOJpO82XaM_Xr9Bh-4zkzWtU3f7N540955Nrz_Byizc-5vd6h8EjxQmxMpKvYxTblV1iUzt8vVy064_tDV63eXn1Apph0rvGNlceD7WNb9D89Mf8-1nePZ6QV4IUu9xzXholpaKeQVBUeadE5csgJ-CxBBFIsOAZuSJ4BxGHLCBYNcYpJ4yTKjB2hPbrVe3fIgxE3EZctYoxTgtRMm4JsUCuDHHVJEOk56WuOmDx-L7FlU4X3Ezplv8a-K8T_zXN0JeBZt3Cavx39Le4RMPICImdGlabhe5EREtCPLXGBFYoHhg1EXPXOlFJL4MyMkPH_QLrTk-3GsJjEBUFApOhT0M3aFi8NjG1XzXtmJJQsIYZKkaCMZrQuKde_klY3RCAFxDSZehrL0L_Pv74D7972vD36BmNwh1PncUx2t9tGv8BfKWd_dgpxx06xxBP
  priority: 102
  providerName: Springer Nature
Title α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation
URI https://link.springer.com/article/10.1038/s41467-021-24376-2
https://www.proquest.com/docview/2548448918
https://www.proquest.com/docview/2548912030
https://pubmed.ncbi.nlm.nih.gov/PMC8257576
https://doaj.org/article/611e2baaf3784f32a5399bd5c6e6f8a6
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1fb9MwELfGJiReEH9FYFRG4g0CdezYzgNCXbUyFW1C0El9i-zY7ip1aWkbiX4svgifibOTFGUaSLwkkv8kzuXOd2f7fofQa5clxoAmjVlKdcycSmEeZCr2UZBK2MQQ7dc7zi_42SUbT9PpAWrTHTUE3Nzq2vl8Upfrxbsf33cfQeA_1CHj8v2GBXH3hw08vB6PYUo-As0kfEaD88bcDzMzzcCh8RvNSZ-RGBrQJo7m9sd0dFWA9O_YoTdPUd7YSg0aavQA3W9MSzyoeeEhOrDlI3S3Tja5e4yKXz_jSaU_s_61pXi-wWvrTwFbg8FuxQHX0ndfeYI0wZlYlQZfz2c1l2C9w6v69F45g2IY9LbS1cLifQTkEzQZnU6GZ3GTYiEuUiK2sWUsU5JzmVgKrlNhjUwLmzneB7vGpY44DfaTEc4a8Eu4AJdWKSNNqgyXjtKn6LBclvYZwtCJaY--VlDKEpFmlGlCNHSXipiiHyHS0jIvGvhxnwVjkYdtcCrzmv450D8P9M-TCL3Z91nV4Bv_bH3if9G-pQfODgXL9Sxv5DDnhNhEK-WokMzRRHlkXm3SglvupOIROm5_cN4yYw5ONLCNBOaJ0Kt9Ncih31xRpV1WdZuMJDBnRkh0GKMzoG5NOb8KiN7gpgtw_CL0tmWhPy__-wc__y_yvED3Es_bfmk6PUaH23VlX4JBtdU9dEdMBVzl6FMPHQ0G429juJ-cXnz5CqVDPuyFpYpekKbfRBEguQ
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELaqIgQXVF5iaQEjwQlWjR_r9R4Q4hVS0vYUpN4se22HSO0m5CGUH8WBP8JvYmYfqVKJ3nrdtbXe8XhenvmGkFex4N6DJk1lJlwqo81ADkqbYhWkzQP3zGG84-RUDb7Lb2fZ2Q753dXCYFplJxNrQe2nJcbID8GR0eBKFEy_n_1MsWsU3q52LTQathiG9S9w2Rbvjj7D_r7mvP9l9GmQtl0F0jJj-TINUhZWK6V5EOAtlMHrrAxFVD1Q5TGLLDowGXwegwdTXOXgxVnrtc-sVzpi_BMk_i0pQJFjYXr_6yakg2DrsMa2NKcn9OFC1oII0yAQ-E-lfEv91V0Ctkzbq4mZV25na6XX3yP3WmuVfmjY6z7ZCdUDcrvpX7l-SMq_f9LRyg1l7yIIOlnQecDE4uApmMK0hsrE6TN0n9t6T2orTy8m44bxqFvTWZMQWI3hMSx6uXKr80A3RZWPyOgm6PuY7FbTKjwhFCZJh4BupRCS51khpGPMwXRtmS97CWEdLU3ZIppjY41zU9-sC20a-hugv6npb3hC3mzmzBo8j2tHf8Qt2oxELO76wXQ-Nu3RNoqxwJ21UeRaRsEtgv06n5UqqKitSshBt8GmFRALc8nOCXm5eQ1HG-9rbBWmq2ZMwTiI4YTkW4yxtaDtN9XkRw0SDp5_Dr5kQt52LHT58f__8NPr1_qC3BmMTo7N8dHpcJ_c5cjYGOrODsjucr4Kz8BAW7rn9bGgxNzwMfwHRJ9N_A
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELaqVCAuqLzEQgEjwQlWib1er_eAEKWNWgJRhYLUm2Wv7RCp3aR5COVnceRP8JuY2UeqVKK3XndtrXc8M54Zz3xDyJuQc-fgJI1FmthYBJOCHhQmxipIk3numMV4x7ehPP4hvpylZzvkT1sLg2mVrU6sFLWbFhgj74Ijo8CVyJnqhiYt4vSw_3F2GWMHKbxpbdtp1Cwy8Otf4L4tPpwcwl6_5bx_NPp8HDcdBuIiZdky9kLkRkmpuE_Acyi8U2nh8yB7cKyHNLBgwXxwWfAOzHKZgUdnjFMuNU6qgLFQ0P67GTpFHbJ7cDQ8_b4J8CD0Oqy4KdTpJaq7EJVawqQIhAGUMd86DKueAVuG7vU0zWt3tdUR2N8j9xvblX6qme0B2fHlQ3Kn7ma5fkSKv7_j0coORO_CJ3SyoHOPacbeUTCMaQWcidNn6Ew31Z_UlI5eTMY1G1K7prM6PbAcw2NY9HJlV-eebkosH5PRbVD4CemU09I_JRQmCYvwbkWSCJ6leSIsYxamK8Nc0YsIa2mpiwbfHNtsnOvqnj1Ruqa_Bvrriv6aR-TdZs6sRve4cfQBbtFmJCJzVw-m87FuBF1Lxjy3xoQkUyIk3CD0r3VpIb0MysiI7LcbrBt1sdBXzB2R15vXIOh4e2NKP13VY3LGQSlHJNtijK0Fbb8pJz8ryHAFmhk8y4i8b1no6uP__-FnN6_1FbkLIqi_ngwHz8k9jnyNce90n3SW85V_Adba0r5s5IISfcuS-A9RWlOO
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%CE%B1-TubK40me3+is+required+for+neuronal+polarization+and+migration+by+promoting+microtubule+formation&rft.jtitle=Nature+communications&rft.au=Xie%2C+Xuan&rft.au=Wang%2C+Shaogang&rft.au=Li%2C+Mingyi&rft.au=Diao%2C+Lei&rft.date=2021-07-05&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=12&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-021-24376-2&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41467_021_24376_2
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon