Structure and immune recognition of the porcine epidemic diarrhea virus spike protein

• Published in: Structure (London) Vol. 29; no. 4; pp. 385 - 392.e5
• Main Authors: Kirchdoerfer, Robert N., Bhandari, Mahesh, Martini, Olnita, Sewall, Leigh M., Bangaru, Sandhya, Yoon, Kyoung-Jin, Ward, Andrew B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.04.2021
• Subjects: Animals; Antibodies, Viral - metabolism; Cell Line; Coronavirus Infections - immunology; Cryoelectron Microscopy; Epitopes - immunology; Fatty Acids, Monounsaturated - chemistry; glycoprotein; Models, Molecular; Molecular Conformation; palmitoleic acid; polyclonal antibody; Polysaccharides - chemistry; porcine epidemic diarrhea virus; Porcine epidemic diarrhea virus - chemistry; Porcine epidemic diarrhea virus - immunology; Porcine epidemic diarrhea virus - metabolism; Protein Binding; Sf9 Cells; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Swine; palmitoleic acid; glycoprotein; cryoelectron microscopy; porcine epidemic diarrhea virus; polyclonal antibody

Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus responsible for significant morbidity and mortality in pigs. A key determinant of viral tropism and entry, the PEDV spike protein is a key target for the host antibody response and a good candidate for a protein-based vaccine immunogen. W...