Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, combretastatin A4 - Charalambous, Antonia; Mico, Victoria; McVeigh, Laura E.; Marston, Gemma; Ingram, Nicola; Volpato, Milène; Peyman, Sally A.; McLaughlan, James R.; Wierzbicki, Antonia; Loadman, Paul M.; Bushby, Richard J.; Markham, Alexander F.; et al. (Nanomedicine, 2021)
Keywords: Animals; Cell Line, Tumor; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Combretastatin A4; Humans; Hydrophobic and Hydrophilic Interactions; Lipid-Oil-Nanodroplets (LONDs); Lipids - chemistry; Lipids - pharmacokinetics; Lipids - pharmacology; Mice; Mice, Inbred BALB C; Mice, Nude; Microbubbles; Nanostructures - chemistry; Nanostructures - therapeutic use; Stilbenes - chemistry; Stilbenes - pharmacokinetics; Stilbenes - pharmacology; Targeting; Ultrasonography; Ultrasound trigger; Xenograft Model Antitumor Assays; LOD; VEGFR2; Combretastatin A4; Targeting; Tx; CA4P; EPR; Ultrasound trigger; i.p; ICAM-1; CA4G; LONDs; i.v; Lipid-Oil-Nanodroplets (LONDs); VDA; CRC; CA4; TGI; Microbubbles; CEPs; US; 5-FU; MBs