Fly Fishing for Histones: Catch and Release by Histone Chaperone Intrinsically Disordered Regions and Acidic Stretches

• Published in: Journal of molecular biology Vol. 429; no. 16; pp. 2401 - 2426
• Main Authors: Warren, Christopher, Shechter, David
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 04.08.2017
• Subjects: chromatin; Chromatin - metabolism; histone chaperone; Histone Chaperones - chemistry; Histone Chaperones - metabolism; histones; Histones - metabolism; Humans; intrinsically disordered proteins; Models, Biological; Models, Molecular; Nucleosomes - metabolism; post-translational modifications; Protein Binding; Protein Conformation; Saccharomyces cerevisiae - metabolism; Asf1; CAF-1; hSpt2; HJURP; PTM; CTAD; FACT; CABIN1; histones; NLS; IDP; IDR; UBN1; post-translational modifications; Nap1L1; Npm2; DAXX; TTLL; chromatin; histone chaperone; PML; Nap1; CTD; HDX-MS; APLF; intrinsically disordered proteins; RAPID

Chromatin is the complex of eukaryotic DNA and proteins required for the efficient compaction of the nearly 2-meter-long human genome into a roughly 10-micron-diameter cell nucleus. The fundamental repeating unit of chromatin is the nucleosome: 147bp of DNA wrapped about an octamer of histone protei...