PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway

• Published in: Cell death & disease Vol. 12; no. 6; pp. 552 - 14
• Main Authors: Han, Zhiqiang, Liu, Dongming, Chen, Lu, He, Yuchao, Tian, Xiangdong, Qi, Lisha, Chen, Liwei, Luo, Yi, Chen, Ziye, Hu, Xiaomeng, Li, Guangtao, Zhan, Linlin, Wang, Yu, Li, Qiang, Chen, Peng, Liu, Zhiyong, Guo, Hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.05.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/2; 631/67/69; 692/699/67/69; Antibodies; Apoptosis; Autophagy; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell proliferation; Hepatocellular carcinoma; Immunology; Life Sciences; Liver cancer; MAP kinase; Molecular modelling; Paraffin; Phagocytosis; Polymerase chain reaction; Ribosomes; RNA-binding protein; Signal transduction; Tumors; Western blotting

Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1 is a critical ribosome rarely reported in human tumors. This study aimed to explore the molecular mechanisms of PNO1 in HCC....