The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition

• Published in: Nature communications Vol. 13; no. 1; p. 5440
• Main Authors: Motozono, Chihiro, Toyoda, Mako, Tan, Toong Seng, Hamana, Hiroshi, Goto, Yoshihiko, Aritsu, Yoshiki, Miyashita, Yusuke, Oshiumi, Hiroyuki, Nakamura, Kimitoshi, Okada, Seiji, Udaka, Keiko, Kitamatsu, Mizuki, Kishi, Hiroyuki, Ueno, Takamasa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/31; 42; 42/109; 42/70; 45/22; 45/23; 45/44; 45/77; 631/250/1619/554; 631/250/254; 631/250/255/2514; 631/326/596/4130; 64/60; 82/80; 82/83; 96; Antibodies; Antibody response; Antigen presentation; Antigen processing; Antigens; Antiviral activity; CD8 antigen; Cell activation; Cell recognition; Disease resistance; Epitopes; Histocompatibility antigen HLA; Humanities and Social Sciences; Immune response; Immune response (cell-mediated); Immune system; Lymphocytes; Lymphocytes T; multidisciplinary; Mutagenesis; Mutation; N-Terminus; Peptidase; Peptidases; Proteins; Recognition; Replication; Science; Science (multidisciplinary); Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Spike protein; T cell receptors; Tripeptidylpeptidase II; Vaccines; Viruses

Although the Omicron variant of the SARS-CoV-2 virus shows resistance to neutralizing antibody, it retains susceptibility to the cellular immune response. Here we characterize vaccine-induced T cells specific for various SARS-CoV-2 variants and identified HLA-A*24:02-restricted CD8 + T cells that st...