Kallistatin limits abdominal aortic aneurysm by attenuating generation of reactive oxygen species and apoptosis

• Published in: Scientific reports Vol. 11; no. 1; pp. 17451 - 15
• Main Authors: Krishna, Smriti Murali, Li, Jiaze, Wang, Yutang, Moran, Corey S., Trollope, Alexandra, Huynh, Pacific, Jose, Roby, Biros, Erik, Ma, Jianxing, Golledge, Jonathan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4019/592; 692/4019/592/75; 692/4019/592/75/593; 692/4019/592/75/593/1287; Angiotensin; Angiotensin II; Animal models; Aorta; Aortic aneurysms; Apoptosis; Calcium phosphates; Elastin; Humanities and Social Sciences; Inflammation; multidisciplinary; Oxidative stress; Proteinase; Proteinase inhibitors; Reactive oxygen species; Science; Science (multidisciplinary); Serine; Serine proteinase; Serine proteinase inhibitors; Smooth muscle; Thrombosis

Inflammation, vascular smooth muscle cell apoptosis and oxidative stress are believed to play important roles in abdominal aortic aneurysm (AAA) pathogenesis. Human kallistatin (KAL; gene SERPINA4 ) is a serine proteinase inhibitor previously shown to inhibit inflammation, apoptosis and oxidative st...