Blood–brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication

• Published in: Scientific reports Vol. 12; no. 1; pp. 16147 - 9
• Main Authors: Chien, Chih-Yen, Xu, Lu, Pacia, Christopher Pham, Yue, Yimei, Chen, Hong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647; 631/61; Animal models; Blood-brain barrier; Cavitation; Feedback; Hemorrhage; Humanities and Social Sciences; Membrane permeability; multidisciplinary; Permeability; Science; Science (multidisciplinary); Sonication; Ultrasonic imaging; Ultrasound

Focused ultrasound (FUS) in combination with microbubbles has been established as a promising technique for noninvasive and localized Blood–brain barrier (BBB) opening. Real-time passive cavitation detection (PCD)-based feedback control of the FUS sonication is critical to ensure effective BBB openi...