Roles of ROS and cell cycle arrest in the genotoxicity induced by gold nanorod core/silver shell nanostructure

• Published in: Nanoscale research letters Vol. 15; no. 1; pp. 224 - 13
• Main Authors: Wang, Dan, Dan, Mo, Ji, Yinglu, Wu, Xiaochun, Wang, Xue, Wen, Hairuo
• Format: Journal Article
• Language: English
• Published: New York Springer US 07.12.2020; Springer Nature B.V; SpringerOpen
• Subjects: Bioassays; Cell cycle; Cell cycle arrest; Chemistry and Materials Science; Chromosomes; Clastogenicity; Comet assay; Comet nuclei; Damage detection; Deoxyribonucleic acid; DNA; DNA damage; Genotoxicity; Gold; Gold nanorod core/silver shell nanostructures; HepaRG cells; Materials Science; Molecular Medicine; Nano Express; Nanochemistry; Nanoparticles; Nanorods; Nanoscale Science and Technology; Nanostructure; Nanotechnology; Nanotechnology and Microengineering; Oxidative stress; Silver; Silver ions; Cell cycle arrest; Oxidative stress; Gold nanorod core/silver shell nanostructures; HepaRG cells; Genotoxicity; Silver ions

To understand the genotoxicity induced in the liver by silver nanoparticles (AgNPs) and silver ions, an engineered gold nanorod core/silver shell nanostructure (Au@Ag NR) and humanized hepatocyte HepaRG cells were used in this study. The involvement of oxidative stress and cell cycle arrest in the D...