Silibinin-modified Hydroxyapatite coating promotes the osseointegration of titanium rods by activation SIRT1/SOD2 signaling pathway in diabetic rats

• Published in: Journal of materials science. Materials in medicine Vol. 33; no. 9; pp. 62 - 14
• Main Authors: Tao, Zhou-Shan, Wang, Hai-Sheng, Li, Tian-Lin, Wei, Shan
• Format: Journal Article
• Language: English
• Published: New York Springer US 04.09.2022; Springer Nature B.V; Springer
• Subjects: Alizarin; Alkaline phosphatase; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Cell viability; Ceramics; Chemistry and Materials Science; Cholecystokinin; Composites; Delivery Systems; Diabetes; Diabetes mellitus; Differentiation (biology); FOXO1 protein; Glass; Hydroxyapatite; Hyperglycemia; Immunofluorescence; Materials Science; Natural Materials; Osseointegration; Oxidative stress; Polymer Sciences; Prostheses; Protective coatings; Recovery of function; Regenerative Medicine/Tissue Engineering; Rodents; Rods; Signal transduction; Signaling; Silibinin; SIRT1 protein; Staining; Superoxide dismutase; Surfaces and Interfaces; Surgical implants; Thin Films; Titanium

The purpose of this study is to investigate the role of Silibinin (SIL)-modified Hydroxyapatite coating on osseointegration in diabetes in vivo and in vitro and explore the mechanism of osteogenic differentiation of MC3T3-E1. RT-qPCR, Immunofluorescence, and Western blot were used to measure the exp...