The Protective Effects of α-Mangostin Attenuate Sodium Iodate-Induced Cytotoxicity and Oxidative Injury via Mediating SIRT-3 Inactivation via the PI3K/AKT/PGC-1α Pathway

• Published in: Antioxidants Vol. 10; no. 12; p. 1870
• Main Authors: Chuang, Chen-Ju, Wang, Meilin, Yeh, Jui-Hsuan, Chen, Tzu-Chun, Tsou, Shang-Chun, Lee, Yi-Ju, Chang, Yuan-Yen, Lin, Hui-Wen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.11.2021; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; Age; age-related macular degeneration (AMD); AKT protein; alpha-mangostin (α-MG); Animals; antiapoptotic; antioxidant; Antioxidants; Apoptosis; Bax protein; Bcl-2 protein; Biosynthesis; Blindness; Caspase-3; Catalase; Cell viability; Cytotoxicity; deformation; elderly; Enzymatic activity; epithelium; Flow cytometry; Glutathione; humans; Hydrogen peroxide; Kinases; Macular degeneration; Medical research; Neurodegeneration; Neurodegenerative diseases; Older people; Oxidative stress; oxidative toxicity; pathogenesis; Photoreceptors; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase 1; protective effect; protein synthesis; Reactive oxygen species; Retina; retinal pigment epithelial (RPE); sodium; Superoxide dismutase; toxicity testing; United Kingdom > UK; Ann Arbor Michigan; United States > US; antioxidant; age-related macular degeneration (AMD); antiapoptotic; alpha-mangostin (α-MG); retinal pigment epithelial (RPE); oxidative stress

It is well known that age-related macular degeneration (AMD) is an irreversible neurodegenerative disease that can cause blindness in the elderly. Oxidative stress-induced retinal pigment epithelial (RPE) cell damage is a part of the pathogenesis of AMD. In this study, we evaluated the protective ef...