The Protective Effects of α-Mangostin Attenuate Sodium Iodate-Induced Cytotoxicity and Oxidative Injury via Mediating SIRT-3 Inactivation via the PI3K/AKT/PGC-1α Pathway - Chuang, Chen-Ju; Wang, Meilin; Yeh, Jui-Hsuan; Chen, Tzu-Chun; Tsou, Shang-Chun; Lee, Yi-Ju; Chang, Yuan-Yen; Lin, Hui-Wen (Antioxidants, 2021)
Keywords: 1-Phosphatidylinositol 3-kinase; Age; age-related macular degeneration (AMD); AKT protein; alpha-mangostin (α-MG); Animals; antiapoptotic; antioxidant; Antioxidants; Apoptosis; Bax protein; Bcl-2 protein; Biosynthesis; Blindness; Caspase-3; Catalase; Cell viability; Cytotoxicity; deformation; elderly; Enzymatic activity; epithelium; Flow cytometry; Glutathione; humans; Hydrogen peroxide; Kinases; Macular degeneration; Medical research; Neurodegeneration; Neurodegenerative diseases; Older people; Oxidative stress; oxidative toxicity; pathogenesis; Photoreceptors; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase 1; protective effect; protein synthesis; Reactive oxygen species; Retina; retinal pigment epithelial (RPE); sodium; Superoxide dismutase; toxicity testing; United Kingdom--UK; Ann Arbor Michigan; United States--US; antioxidant; age-related macular degeneration (AMD); antiapoptotic; alpha-mangostin (α-MG); retinal pigment epithelial (RPE); oxidative stress