Vascular Smooth Muscle Cells Differ from Other Smooth Muscle Cells: Predominance of Vimentin Filaments and a Specific α -Type Actin

Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-sized filament constituent and also show a predominance of γ -type smooth muscle actin. We have now examined smooth muscle tissue of different blood vessels (e.g., a...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 78; no. 1; pp. 298 - 302
Main Authors Gabbiani, Giulio, Schmid, Erika, Winter, Stefanie, Chaponnier, Christine, De Chastonay, Catherine, Vandekerckhove, Joel, Weber, Klaus, Franke, Werner W.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences of the United States of America 01.01.1981
National Acad Sciences
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Abstract Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-sized filament constituent and also show a predominance of γ -type smooth muscle actin. We have now examined smooth muscle tissue of different blood vessels (e.g., aorta, small arteries, arterioles, venules, and vena cava) from various mammals (man, cow, pig, rabbit, rat) by one- and two-dimensional gel electrophoresis of cell proteins and by immunofluorescence microscopy using antibodies to different intermediate-sized filament proteins. Intermediate-sized filaments of vascular smooth muscle cells contain abundant amounts of vimentin and little, if any, desmin. On gel electrophoresis, vascular smooth muscle vimentin appears as two isoelectric variants of apparent pI values of 5.30 and 5.29, shows the characteristic series of proteolytic fragments, and is one of the major cell proteins. Thus vimentin has been demonstrated in a smooth muscle cell present in the body. Vascular smooth muscle cells are also distinguished by the predominance of a smooth muscle-specific α -type actin, whereas γ -type smooth muscle actin is present only as a minor component. It is proposed that the intermediate filament and actin composition of vascular smooth muscle cells reflects a differentiation pathway separate from that of other smooth muscle cells and may be related to special functions and pathological disorders of blood vessels.
AbstractList Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-size filament constituent and also show a predominance of gamma-type smooth muscle actin. We have now examined smooth muscle tissue of different blood vessels (e.g., aorta, small arteries, arterioles, venules, and vena cava) from various mammals (man, cow, pig, rabbit, rat) by one- and two-dimensional gel electrophoresis of cell proteins and by immunofluorescence microscopy using antibodies to different intermediate-sized filament proteins. Intermediate-sized filaments of vascular smooth muscle cells contain abundant amounts of vimentin and little, if any, desmin. On gel electrophoresis, vascular smooth muscle vimentin appears as two isoelectric variants of apparent pI values of 5.30 and 5.29, shows the characteristic series of proteolytic fragments, and is one of the major cell proteins. Thus vimentin has been demonstrated in a smooth muscle cell present in the body. Vascular smooth muscle cells are also distinguished by the predominance of a smooth muscle-specific alpha-type actin, whereas gamma-type smooth muscle actin is present only as a minor component. It is proposed that the intermediate filament and actin composition of vascular smooth muscle cells reflects a differentiation pathway separate from that of other smooth muscle cells and may be related to special functions and pathological disorders of blood vessels.
Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-sized filament constituent and also show a predominance of γ -type smooth muscle actin. We have now examined smooth muscle tissue of different blood vessels (e.g., aorta, small arteries, arterioles, venules, and vena cava) from various mammals (man, cow, pig, rabbit, rat) by one- and two-dimensional gel electrophoresis of cell proteins and by immunofluorescence microscopy using antibodies to different intermediate-sized filament proteins. Intermediate-sized filaments of vascular smooth muscle cells contain abundant amounts of vimentin and little, if any, desmin. On gel electrophoresis, vascular smooth muscle vimentin appears as two isoelectric variants of apparent pI values of 5.30 and 5.29, shows the characteristic series of proteolytic fragments, and is one of the major cell proteins. Thus vimentin has been demonstrated in a smooth muscle cell present in the body. Vascular smooth muscle cells are also distinguished by the predominance of a smooth muscle-specific α -type actin, whereas γ -type smooth muscle actin is present only as a minor component. It is proposed that the intermediate filament and actin composition of vascular smooth muscle cells reflects a differentiation pathway separate from that of other smooth muscle cells and may be related to special functions and pathological disorders of blood vessels.
Author Winter, Stefanie
Weber, Klaus
De Chastonay, Catherine
Vandekerckhove, Joel
Chaponnier, Christine
Franke, Werner W.
Gabbiani, Giulio
Schmid, Erika
Author_xml – sequence: 1
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  surname: Gabbiani
  fullname: Gabbiani, Giulio
– sequence: 2
  givenname: Erika
  surname: Schmid
  fullname: Schmid, Erika
– sequence: 3
  givenname: Stefanie
  surname: Winter
  fullname: Winter, Stefanie
– sequence: 4
  givenname: Christine
  surname: Chaponnier
  fullname: Chaponnier, Christine
– sequence: 5
  givenname: Catherine
  surname: De Chastonay
  fullname: De Chastonay, Catherine
– sequence: 6
  givenname: Joel
  surname: Vandekerckhove
  fullname: Vandekerckhove, Joel
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  surname: Weber
  fullname: Weber, Klaus
– sequence: 8
  givenname: Werner W.
  surname: Franke
  fullname: Franke, Werner W.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/7017714$$D View this record in MEDLINE/PubMed
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PMID 7017714
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Snippet Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-sized filament...
Smooth muscle cells of the digestive, respiratory, and urogenital tracts contain desmin as their major, if not exclusive, intermediate-size filament...
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StartPage 298
SubjectTerms Actins
Actins - analysis
Aged
Animals
Antibodies
Aorta
Aorta - analysis
Cattle
Cytoskeleton - analysis
Desmin
Electrophoresis
Electrophoresis, Polyacrylamide Gel
Female
Fluorescent Antibody Technique
Gels
Humans
Male
Microscopy, Fluorescence
Middle Aged
Muscle Proteins - analysis
Muscle tissues
Muscle, Smooth - cytology
Muscle, Smooth, Vascular - cytology
Rabbits
Rats
Smooth muscle
Smooth muscle myocytes
Species Specificity
Swine
Uterus
Vimentin
Title Vascular Smooth Muscle Cells Differ from Other Smooth Muscle Cells: Predominance of Vimentin Filaments and a Specific α -Type Actin
URI https://www.jstor.org/stable/10032
http://www.pnas.org/content/78/1/298.abstract
https://www.ncbi.nlm.nih.gov/pubmed/7017714
https://search.proquest.com/docview/75681203
https://pubmed.ncbi.nlm.nih.gov/PMC319040
Volume 78
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