TMAO: how gut microbiota contributes to heart failure

• Published in: Translational research : the journal of laboratory and clinical medicine Vol. 228; pp. 109 - 125
• Main Authors: Zhang, Yixin, Wang, Yuan, Ke, Bingbing, Du, Jie
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2021
• Subjects: Gastrointestinal Microbiome; Heart Failure - metabolism; Humans; Intestinal Mucosa - metabolism; Methylamines - metabolism; CHF; TMAO; RCT; BNP; LVEF; LV; HFpEF; DASH; HFrEF; TNF; LPS; LVAD; NF-κB; NT-proBNP; DMB; DMA; NLRP3; FMC; IMC; IL; DIM; FMO; PKC; TMA; FMT; SOD2; ER; SCFA; SIRT3; VCAM; TML; TCA; TGF-β1; CVDs; HF; γBB; AHF

An increasing amount of evidence reveals that the gut microbiota is involved in the pathogenesis and progression of various cardiovascular diseases. In patients with heart failure (HF), splanchnic hypoperfusion causes ischemia and intestinal edema, allowing bacterial translocation and bacterial meta...