Whole body creatine and protein kinetics in healthy men and women: effects of creatine and amino acid supplementation

• Published in: Amino acids Vol. 48; no. 3; pp. 677 - 687
• Main Authors: Kalhan, Satish C., Gruca, Lourdes, Marczewski, Susan, Bennett, Carole, Kummitha, China
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.03.2016; Springer Nature B.V
• Subjects: Adult; Amino acids; Amino Acids - blood; Analytical Chemistry; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; Citrulline; Creatine; Creatine - blood; Creatine - chemistry; cysteine; diet; Dietary Supplements - analysis; Dilution; Female; females; Glutamine; Glycine; Healthy Volunteers; Humans; Kinetics; Life Sciences; Lysine; Male; males; Men; Neurobiology; Original Article; Phenylalanine; Protein Biosynthesis; protein metabolism; Protein turnover; Proteins; Proteins - chemistry; Proteins - metabolism; Proteomics; Supplements; Synthesis; Taurine; Valine; Women; Young Adult; Guanidinoacetic acid; Kinetics; Phenylalanine; Creatine; Glycine; Stable isotopes

Creatine kinetics were measured in young healthy subjects, eight males and seven females, age 20-30 years, after an overnight fast on creatine-free diet. Whole body turnover of glycine and its appearance in creatine was quantified using [1-¹³C] glycine and the rate of protein turnover was quantified...