Syntaxin-1a and SNAP-25 expression level is increased in the blood samples of ischemic stroke patients

The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery...

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Published inScientific reports Vol. 12; no. 1; pp. 14483 - 18
Main Authors Cappelletti, Pamela, Filareti, Melania, Masuelli, Laura, Bei, Roberto, Hassanzadeh, Kambiz, Corbo, Massimo, Feligioni, Marco
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.08.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/378
631/45
Biomarkers
Blood flow
Blood levels
Blood-brain barrier
Brain injury
Cerebral blood flow
Cytoplasm
Extracellular vesicles
Humanities and Social Sciences
Ischemia
Membrane permeability
multidisciplinary
Neurological diseases
Patients
Peripheral blood mononuclear cells
Science
Science (multidisciplinary)
SNAP-25 protein
Stroke
Syntaxin
Syntaxin 1
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Abstract The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery. The increased permeability of the blood–brain barrier, following a brain infarct, allows the detection of brain proteins in the blood flow. In this work, we analyzed the expression levels of two synaptic proteins Syntaxin (STX)-1a and Synaptosomal Associated Protein, 25 kDa (SNAP-25), in Peripheral Blood Mononuclear Cell (PBMC), serum and in Neuronal Derived Extracellular vesicles (NDEs) of IS patients, age and sex matched healthy control (HC) and younger HC (Y-HC). Interestingly, we identified STX-1a protein in the cytoplasm of PBMC and both STX-1a and SNAP-25 expression levels were significantly augmented in all IS patient’s blood fractions compared to control subjects. In addition, STX-1a blood levels correlated with the IS clinical scales National Institutes of Health Stroke Scale (NIH-SS) and the modified Barthel Index (BI). These results prompted us to speculate that STX-1a and SNAP-25 hematic fluctuations depict the brain damage after an ischemic attack and that their hematic detection could represent a novel and accessible IS biomarkers.
AbstractList The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery. The increased permeability of the blood–brain barrier, following a brain infarct, allows the detection of brain proteins in the blood flow. In this work, we analyzed the expression levels of two synaptic proteins Syntaxin (STX)-1a and Synaptosomal Associated Protein, 25 kDa (SNAP-25), in Peripheral Blood Mononuclear Cell (PBMC), serum and in Neuronal Derived Extracellular vesicles (NDEs) of IS patients, age and sex matched healthy control (HC) and younger HC (Y-HC). Interestingly, we identified STX-1a protein in the cytoplasm of PBMC and both STX-1a and SNAP-25 expression levels were significantly augmented in all IS patient’s blood fractions compared to control subjects. In addition, STX-1a blood levels correlated with the IS clinical scales National Institutes of Health Stroke Scale (NIH-SS) and the modified Barthel Index (BI). These results prompted us to speculate that STX-1a and SNAP-25 hematic fluctuations depict the brain damage after an ischemic attack and that their hematic detection could represent a novel and accessible IS biomarkers.
The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery. The increased permeability of the blood–brain barrier, following a brain infarct, allows the detection of brain proteins in the blood flow. In this work, we analyzed the expression levels of two synaptic proteins Syntaxin (STX)-1a and Synaptosomal Associated Protein, 25 kDa (SNAP-25), in Peripheral Blood Mononuclear Cell (PBMC), serum and in Neuronal Derived Extracellular vesicles (NDEs) of IS patients, age and sex matched healthy control (HC) and younger HC (Y-HC). Interestingly, we identified STX-1a protein in the cytoplasm of PBMC and both STX-1a and SNAP-25 expression levels were significantly augmented in all IS patient’s blood fractions compared to control subjects. In addition, STX-1a blood levels correlated with the IS clinical scales National Institutes of Health Stroke Scale (NIH-SS) and the modified Barthel Index (BI). These results prompted us to speculate that STX-1a and SNAP-25 hematic fluctuations depict the brain damage after an ischemic attack and that their hematic detection could represent a novel and accessible IS biomarkers.
The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery. The increased permeability of the blood-brain barrier, following a brain infarct, allows the detection of brain proteins in the blood flow. In this work, we analyzed the expression levels of two synaptic proteins Syntaxin (STX)-1a and Synaptosomal Associated Protein, 25 kDa (SNAP-25), in Peripheral Blood Mononuclear Cell (PBMC), serum and in Neuronal Derived Extracellular vesicles (NDEs) of IS patients, age and sex matched healthy control (HC) and younger HC (Y-HC). Interestingly, we identified STX-1a protein in the cytoplasm of PBMC and both STX-1a and SNAP-25 expression levels were significantly augmented in all IS patient's blood fractions compared to control subjects. In addition, STX-1a blood levels correlated with the IS clinical scales National Institutes of Health Stroke Scale (NIH-SS) and the modified Barthel Index (BI). These results prompted us to speculate that STX-1a and SNAP-25 hematic fluctuations depict the brain damage after an ischemic attack and that their hematic detection could represent a novel and accessible IS biomarkers.The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery. The increased permeability of the blood-brain barrier, following a brain infarct, allows the detection of brain proteins in the blood flow. In this work, we analyzed the expression levels of two synaptic proteins Syntaxin (STX)-1a and Synaptosomal Associated Protein, 25 kDa (SNAP-25), in Peripheral Blood Mononuclear Cell (PBMC), serum and in Neuronal Derived Extracellular vesicles (NDEs) of IS patients, age and sex matched healthy control (HC) and younger HC (Y-HC). Interestingly, we identified STX-1a protein in the cytoplasm of PBMC and both STX-1a and SNAP-25 expression levels were significantly augmented in all IS patient's blood fractions compared to control subjects. In addition, STX-1a blood levels correlated with the IS clinical scales National Institutes of Health Stroke Scale (NIH-SS) and the modified Barthel Index (BI). These results prompted us to speculate that STX-1a and SNAP-25 hematic fluctuations depict the brain damage after an ischemic attack and that their hematic detection could represent a novel and accessible IS biomarkers.
Abstract The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in blood samples would be revolutionary allowing a fast and better pathology prediction or outcome and to collect information on patient recovery. The increased permeability of the blood–brain barrier, following a brain infarct, allows the detection of brain proteins in the blood flow. In this work, we analyzed the expression levels of two synaptic proteins Syntaxin (STX)-1a and Synaptosomal Associated Protein, 25 kDa (SNAP-25), in Peripheral Blood Mononuclear Cell (PBMC), serum and in Neuronal Derived Extracellular vesicles (NDEs) of IS patients, age and sex matched healthy control (HC) and younger HC (Y-HC). Interestingly, we identified STX-1a protein in the cytoplasm of PBMC and both STX-1a and SNAP-25 expression levels were significantly augmented in all IS patient’s blood fractions compared to control subjects. In addition, STX-1a blood levels correlated with the IS clinical scales National Institutes of Health Stroke Scale (NIH-SS) and the modified Barthel Index (BI). These results prompted us to speculate that STX-1a and SNAP-25 hematic fluctuations depict the brain damage after an ischemic attack and that their hematic detection could represent a novel and accessible IS biomarkers.
ArticleNumber 14483
Author Corbo, Massimo
Feligioni, Marco
Filareti, Melania
Masuelli, Laura
Cappelletti, Pamela
Bei, Roberto
Hassanzadeh, Kambiz
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Cites_doi 10.3340/jkns.2017.0200
10.1177/1747493017711816
10.1038/nrn.2015.29
10.3389/fncel.2020.00051
10.1002/eji.201141915
10.1002/elps.200500964
10.1161/01.str.31.1.77
10.1073/pnas.1617981114
10.1038/mp.2008.148
10.1016/j.neuron.2014.04.020
10.1016/j.brainres.2009.03.047
10.1146/annurev-cellbio-101512-122326
10.1182/blood.V93.8.2617
10.1161/01.str.30.10.2174
10.1523/JNEUROSCI.0289-06.2006
10.1016/j.mcn.2005.12.003
10.1212/wnl.55.7.952
10.1002/jlb.65.3.397
10.3389/fnins.2017.00278
10.1016/j.bbadis.2009.09.003
10.1038/sj.mp.4001247
10.1111/j.1600-079X.2009.00709.x
10.2165/00019053-200422004-00004
10.1128/cdli.1.3.261-268.1994
10.18632/oncotarget.12902
10.1007/s00018-018-2773-4
10.3389/fphys.2012.00228
10.4049/jimmunol.179.6.3397
10.1186/s13195-015-0124-3
10.1177/1747493017714176
10.1016/j.neurol.2016.02.003
10.1161/01.CIR.0000152105.79665.C6
10.1016/0022-3956(75)90026-6
10.1113/jphysiol.2004.064899
10.1001/archneur.61.3.346
10.1159/000505160
10.1016/j.heliyon.2019.e02590
10.1017/S1461145708009036
10.21769/BioProtoc.323
10.1002/mc.23129
10.1161/01.str.12.6.723
10.1172/JCI81133
10.1371/journal.pone.0179065
10.1038/s41598-017-04017-9
10.1212/wnl.53.1.126
10.1158/2326-6066.CIR-17-0604
10.1091/mbc.e04-03-0182
10.1016/j.xphs.2016.07.022
10.1111/j.1532-5415.1968.tb02103.x
10.1161/01.str.23.9.1367
10.1161/01.STR.0000153069.96296.fd
10.1186/s12874-017-0409-2
10.3389/fphys.2012.00063
10.1006/bbrc.1997.7515
10.1016/j.nbd.2020.105185
10.1023/b:bebm.0000035130.80245.13
10.1007/s004010050795
10.2741/4647
10.1111/j.1460-9568.2004.03600.x
10.1016/j.pathophys.2009.12.001
10.1007/s12035-019-1501-x
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References Wang (CR14) 2017; 7
Lai, Breakefield (CR23) 2012; 3
Moore (CR47) 2005; 111
Kostulas, Pelidou, Kivisakk, Kostulas, Link (CR60) 1999; 30
Bernhardt (CR54) 2017; 12
Mustapic (CR41) 2017; 11
Fujiwara (CR49) 2006; 26
Agliardi (CR30) 2019; 56
Hou (CR48) 2004; 20
Etain (CR13) 2010; 15
Cao, Hata, Zhu, Niinobe, Sakanaka (CR16) 2009; 1272
Deb, Sharma, Hassan (CR1) 2010; 17
Romain (CR3) 2019; 54
Larry-Sparks (CR37) 2012; 1
Pattu (CR29) 2012; 42
Borrelli (CR42) 2018; 6
Sims, Muyderman (CR9) 2010; 1802
Reed, Houng, Fitzgerald (CR52) 1999; 93
Chen (CR27) 2016; 7
Linn, Linn, Gurel (CR35) 1968; 16
Nabokina, Egea, Blasi, Mollinedo (CR50) 1997; 239
Peak (CR62) 2020; 59
Agliardi (CR32) 2021; 148
Colombo, Borgiani, Verderio, Furlan (CR26) 2012; 3
Kvartsberg (CR21) 2015; 7
Arneson (CR58) 2007; 179
Pei, Maitta (CR59) 2019; 5
Matsumoto (CR22) 2017; 106
Zhang, Chopp (CR45) 2016; 126
Colombo, Raposo, Théry (CR24) 2014; 30
CR43
Lo, Moskowitz, Jacobs (CR8) 2005; 36
Boyd (CR55) 2017; 12
Folstein, Folstein, McHugh (CR36) 1975; 12
Kochanek, Hallenbeck (CR46) 1992; 23
Astrup, Siesjo, Symon (CR7) 1981; 12
Martí, Ferrer, Ballabriga, Blasi (CR17) 1998; 95
Acuna (CR15) 2014; 82
Frankel (CR63) 2000; 55
Adams (CR33) 1999; 53
Mohr (CR40) 2017; 12
Martín-Martín, Nabokina, Lazo, Mollinedo (CR28) 1999; 65
Friberg, Bryant, Shannon, Whiteside (CR56) 1994; 1
Katzan (CR4) 2004; 61
Kustanovich (CR11) 2003; 8
Maestrini (CR19) 2016; 172
Gundacker (CR39) 2006; 27
Redondo (CR53) 2004; 558
Nuyanzina, Nabokina (CR51) 2004; 137
Ohura, Hase, Nakajima, Nakayama (CR34) 2017; 17
Belov-Kirdajova, Kriska, Tureckova, Anderova (CR10) 2020; 14
Bakhai (CR2) 2004; 22
Wang, Rose, Honings, Garwacki, Milbrandt (CR5) 2000; 31
Lin, Li, Liu, Wang (CR6) 2018; 23
Nakamura (CR12) 2008; 11
Karimi (CR44) 2018; 75
Budnik, Ruiz-Canada, Wendler (CR61) 2016; 17
Panda, Ravindran (CR38) 2013; 3
Maa-Bared (CR57) 2004; 15
Fauré (CR25) 2006; 31
Spessott, Sanmillan, McCormick, Kulkarni, Giraudo (CR31) 2017; 114
Choi, Ha, Lim, Kim, Kim (CR20) 2018; 61
Chen (CR18) 2009; 47
A Matsumoto (18719_CR22) 2017; 106
WA Spessott (18719_CR31) 2017; 114
V Kustanovich (18719_CR11) 2003; 8
T Fujiwara (18719_CR49) 2006; 26
IL Katzan (18719_CR4) 2004; 61
JIL Choi (18719_CR20) 2018; 61
P Deb (18719_CR1) 2010; 17
D Friberg (18719_CR56) 1994; 1
N Kostulas (18719_CR60) 1999; 30
S Maa-Bared (18719_CR57) 2004; 15
C Agliardi (18719_CR32) 2021; 148
C Agliardi (18719_CR30) 2019; 56
J Fauré (18719_CR25) 2006; 31
ZG Zhang (18719_CR45) 2016; 126
C Acuna (18719_CR15) 2014; 82
D Larry-Sparks (18719_CR37) 2012; 1
LN Arneson (18719_CR58) 2007; 179
MF Folstein (18719_CR36) 1975; 12
G Romain (18719_CR3) 2019; 54
PM Kochanek (18719_CR46) 1992; 23
T Mohr (18719_CR40) 2017; 12
BS Linn (18719_CR35) 1968; 16
MR Frankel (18719_CR63) 2000; 55
Y Pei (18719_CR59) 2019; 5
KH Chen (18719_CR27) 2016; 7
C Borrelli (18719_CR42) 2018; 6
N Gundacker (18719_CR39) 2006; 27
TC Peak (18719_CR62) 2020; 59
N Karimi (18719_CR44) 2018; 75
J Astrup (18719_CR7) 1981; 12
PC Redondo (18719_CR53) 2004; 558
K Nakamura (18719_CR12) 2008; 11
Y Lin (18719_CR6) 2018; 23
M Colombo (18719_CR24) 2014; 30
D Belov-Kirdajova (18719_CR10) 2020; 14
HP Adams Jr (18719_CR33) 1999; 53
NR Sims (18719_CR9) 2010; 1802
SK Panda (18719_CR38) 2013; 3
E Martí (18719_CR17) 1998; 95
EH Lo (18719_CR8) 2005; 36
HY Chen (18719_CR18) 2009; 47
H Kvartsberg (18719_CR21) 2015; 7
DF Moore (18719_CR47) 2005; 111
S Nabokina (18719_CR50) 1997; 239
DZ Wang (18719_CR5) 2000; 31
A Bakhai (18719_CR2) 2004; 22
E Colombo (18719_CR26) 2012; 3
GL Reed (18719_CR52) 1999; 93
V Pattu (18719_CR29) 2012; 42
B Etain (18719_CR13) 2010; 15
18719_CR43
T Ohura (18719_CR34) 2017; 17
I Maestrini (18719_CR19) 2016; 172
VA Nuyanzina (18719_CR51) 2004; 137
Q Hou (18719_CR48) 2004; 20
M Mustapic (18719_CR41) 2017; 11
J Bernhardt (18719_CR54) 2017; 12
L Boyd (18719_CR55) 2017; 12
B Martín-Martín (18719_CR28) 1999; 65
CPK Lai (18719_CR23) 2012; 3
C Wang (18719_CR14) 2017; 7
V Budnik (18719_CR61) 2016; 17
F Cao (18719_CR16) 2009; 1272
References_xml – volume: 61
  start-page: 548
  issue: 5
  year: 2018
  end-page: 558
  ident: CR20
  article-title: S100ß, matrix metalloproteinase-9, D-dimer, and heat shock protein 70 are serologic biomarkers of acute cerebral infarction in a mouse model of transient MCA occlusion
  publication-title: J. Korean Neurosurg. Soc.
  doi: 10.3340/jkns.2017.0200
– volume: 12
  start-page: 444
  issue: 5
  year: 2017
  end-page: 450
  ident: CR54
  article-title: Agreed definitions and a shared vision for new standards in stroke recovery research: The Stroke Recovery and Rehabilitation Roundtable taskforce
  publication-title: Int. J Stroke.
  doi: 10.1177/1747493017711816
– volume: 17
  start-page: 160
  issue: 3
  year: 2016
  end-page: 172
  ident: CR61
  article-title: Extracellular vesicles round off communication in the nervous system
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2015.29
– volume: 14
  start-page: 1
  year: 2020
  end-page: 27
  ident: CR10
  article-title: Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells
  publication-title: Front. Cell Neurosci.
  doi: 10.3389/fncel.2020.00051
– volume: 42
  start-page: 470
  issue: 2
  year: 2012
  end-page: 475
  ident: CR29
  article-title: SNARE protein expression and localization in human cytotoxic T lymphocytes
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201141915
– volume: 27
  start-page: 2712
  issue: 13
  year: 2006
  end-page: 2721
  ident: CR39
  article-title: Knowledge-based proteome profiling: Considering identified proteins to evaluate separation efficiency by 2-D PAGE
  publication-title: Electrophoresis
  doi: 10.1002/elps.200500964
– volume: 31
  start-page: 77
  issue: 1
  year: 2000
  end-page: 81
  ident: CR5
  article-title: Treating acute stroke patients with intravenous tPA the OSF stroke network experience
  publication-title: Stroke
  doi: 10.1161/01.str.31.1.77
– volume: 114
  start-page: E2176
  issue: 11
  year: 2017
  end-page: E2185
  ident: CR31
  article-title: SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity
  publication-title: Proc. Natl. Acad Sci. USA
  doi: 10.1073/pnas.1617981114
– volume: 15
  start-page: 748
  issue: 7
  year: 2010
  end-page: 755
  ident: CR13
  article-title: A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2008.148
– volume: 82
  start-page: 1088
  issue: 5
  year: 2014
  end-page: 1100
  ident: CR15
  article-title: Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca2+ sensitivity
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.04.020
– volume: 1272
  start-page: 52
  year: 2009
  end-page: 61
  ident: CR16
  article-title: Up-regulation of syntaxin1 in ischemic cortex after permanent focal ischemia in rats
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2009.03.047
– volume: 30
  start-page: 255
  issue: 1
  year: 2014
  end-page: 289
  ident: CR24
  article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-101512-122326
– volume: 93
  start-page: 2617
  issue: 8
  year: 1999
  end-page: 2626
  ident: CR52
  article-title: Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: Implications for platelet secretion
  publication-title: Blood
  doi: 10.1182/blood.V93.8.2617
– volume: 30
  start-page: 2174
  issue: 10
  year: 1999
  end-page: 2179
  ident: CR60
  article-title: Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study
  publication-title: Stroke
  doi: 10.1161/01.str.30.10.2174
– volume: 26
  start-page: 5767
  issue: 21
  year: 2006
  end-page: 5776
  ident: CR49
  article-title: Analysis of knock-out mice to determine the role of HPC-1/syntaxin 1A in expressing synaptic plasticity
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0289-06.2006
– volume: 31
  start-page: 642
  issue: 4
  year: 2006
  end-page: 648
  ident: CR25
  article-title: Exosomes are released by cultured cortical neurones
  publication-title: Mol. Cell Neurosci.
  doi: 10.1016/j.mcn.2005.12.003
– volume: 55
  start-page: 952
  issue: 7
  year: 2000
  end-page: 959
  ident: CR63
  article-title: Predicting prognosis after stroke: A placebo group analysis from the National Institute of Neurological Disorders and Stroke rt-PA Stroke Trial
  publication-title: Neurology
  doi: 10.1212/wnl.55.7.952
– volume: 65
  start-page: 397
  issue: 3
  year: 1999
  end-page: 406
  ident: CR28
  article-title: Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/jlb.65.3.397
– volume: 11
  start-page: 1
  year: 2017
  end-page: 12
  ident: CR41
  article-title: Plasma extracellular vesicles enriched for neuronal origin: A potential window into brain pathologic processes
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2017.00278
– volume: 1802
  start-page: 80
  issue: 1
  year: 2010
  end-page: 91
  ident: CR9
  article-title: Mitochondria, oxidative metabolism and cell death in stroke
  publication-title: Biochim. Biophys. Acta.
  doi: 10.1016/j.bbadis.2009.09.003
– volume: 8
  start-page: 309
  issue: 3
  year: 2003
  end-page: 315
  ident: CR11
  article-title: Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder
  publication-title: Mol. Psychiatry.
  doi: 10.1038/sj.mp.4001247
– volume: 47
  start-page: 260
  issue: 3
  year: 2009
  end-page: 270
  ident: CR18
  article-title: Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats
  publication-title: J. Pineal Res.
  doi: 10.1111/j.1600-079X.2009.00709.x
– volume: 1
  start-page: 99
  issue: 1
  year: 2012
  end-page: 106
  ident: CR37
  article-title: Tau is reduced in AD plasma and validation of employed ELISA methods
  publication-title: Am. J. Neurodegener. Dis.
– volume: 22
  start-page: 11
  issue: Suppl 4
  year: 2004
  end-page: 18
  ident: CR2
  article-title: The burden of coronary, cerebrovascular and peripheral arterial disease
  publication-title: Pharmacoeconomics
  doi: 10.2165/00019053-200422004-00004
– volume: 1
  start-page: 261
  issue: 3
  year: 1994
  end-page: 268
  ident: CR56
  article-title: In vitro cytokine production by normal human peripheral blood mononuclear cells as a measure of immunocompetence or the state of activation
  publication-title: Clin. Diagn. Lab Immunol.
  doi: 10.1128/cdli.1.3.261-268.1994
– volume: 7
  start-page: 74537
  issue: 46
  year: 2016
  end-page: 74556
  ident: CR27
  article-title: Intravenous administration of xenogenic adipose-derived mesenchymal stem cells (ADMSC) and ADMSC-derived exosomes markedly reduced brain infarct volume and preserved neurological function in rat after acute ischemic stroke
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12902
– volume: 75
  start-page: 2873
  issue: 15
  year: 2018
  end-page: 2886
  ident: CR44
  article-title: Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-018-2773-4
– ident: CR43
– volume: 3
  start-page: 1
  year: 2012
  end-page: 14
  ident: CR23
  article-title: Role of exosomes/microvesicles in the nervous system and use in emerging therapies
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2012.00228
– volume: 179
  start-page: 3397
  issue: 6
  year: 2007
  end-page: 3401
  ident: CR58
  article-title: Cutting edge: Syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.6.3397
– volume: 7
  start-page: 40
  issue: 1
  year: 2015
  ident: CR21
  article-title: Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer’s disease patients and healthy controls
  publication-title: Alzheimers Res. Ther.
  doi: 10.1186/s13195-015-0124-3
– volume: 12
  start-page: 480
  issue: 5
  year: 2017
  end-page: 493
  ident: CR55
  article-title: Biomarkers of stroke recovery: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable
  publication-title: Int. J. Stroke.
  doi: 10.1177/1747493017714176
– volume: 172
  start-page: 198
  issue: 3
  year: 2016
  end-page: 219
  ident: CR19
  article-title: Blood biomarkers in the early stage of cerebral ischemia
  publication-title: Rev. Neurol. (Paris)
  doi: 10.1016/j.neurol.2016.02.003
– volume: 111
  start-page: 212
  issue: 2
  year: 2005
  end-page: 221
  ident: CR47
  article-title: Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: A pilot investigation
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000152105.79665.C6
– volume: 12
  start-page: 189
  issue: 3
  year: 1975
  end-page: 198
  ident: CR36
  article-title: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/0022-3956(75)90026-6
– volume: 558
  start-page: 99
  issue: 1
  year: 2004
  end-page: 109
  ident: CR53
  article-title: A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2004.064899
– volume: 61
  start-page: 346
  issue: 3
  year: 2004
  end-page: 350
  ident: CR4
  article-title: Utilization of intravenous tissue plasminogen activator for acute ischemic stroke
  publication-title: Arch Neurol.
  doi: 10.1001/archneur.61.3.346
– volume: 54
  start-page: 498
  issue: 6
  year: 2019
  end-page: 505
  ident: CR3
  article-title: Long-term relative survival after stroke: The dijon stroke registry
  publication-title: Neuroepidemiology
  doi: 10.1159/000505160
– volume: 5
  issue: 10
  year: 2019
  ident: CR59
  article-title: Alpha synuclein in hematopoiesis and immunity
  publication-title: Heliyon
  doi: 10.1016/j.heliyon.2019.e02590
– volume: 11
  start-page: 1073
  issue: 8
  year: 2008
  end-page: 1084
  ident: CR12
  article-title: Genetic and expression analyses reveal elevated expression of syntaxin 1A (STX1A) in high functioning autism
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1017/S1461145708009036
– volume: 3
  issue: 3
  year: 2013
  ident: CR38
  article-title: Isolation of human PBMCs
  publication-title: Bio-Protoc.
  doi: 10.21769/BioProtoc.323
– volume: 59
  start-page: 62
  issue: 1
  year: 2020
  end-page: 72
  ident: CR62
  article-title: Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.23129
– volume: 12
  start-page: 723
  issue: 6
  year: 1981
  end-page: 725
  ident: CR7
  article-title: Thresholds in cerebral ischemia—the ischemic penumbra
  publication-title: Stroke
  doi: 10.1161/01.str.12.6.723
– volume: 126
  start-page: 1190
  issue: 4
  year: 2016
  end-page: 1197
  ident: CR45
  article-title: Exosomes in stroke pathogenesis and therapy
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI81133
– volume: 12
  start-page: 1
  issue: 6
  year: 2017
  end-page: 23
  ident: CR40
  article-title: Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0179065
– volume: 7
  start-page: 1
  issue: 1
  year: 2017
  end-page: 11
  ident: CR14
  article-title: Inhibition of calpains protects Mn-induced neurotransmitter release disorders in synaptosomes from mice: involvement of SNARE complex and synaptic vesicle fusion
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-04017-9
– volume: 53
  start-page: 126
  issue: 1
  year: 1999
  end-page: 131
  ident: CR33
  article-title: Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)
  publication-title: Neurology
  doi: 10.1212/wnl.53.1.126
– volume: 6
  start-page: 860
  issue: 7
  year: 2018
  end-page: 869
  ident: CR42
  article-title: Drug-induced senescent multiple myeloma cells elicit nk cell proliferation by direct or exosome-mediated IL15 trans-presentation
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-17-0604
– volume: 15
  start-page: 5399
  year: 2004
  end-page: 5407
  ident: CR57
  article-title: Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells
  publication-title: Mol. Biol. Cell.
  doi: 10.1091/mbc.e04-03-0182
– volume: 106
  start-page: 168
  issue: 1
  year: 2017
  end-page: 175
  ident: CR22
  article-title: Role of phosphatidylserine-derived negative surface charges in the recognition and uptake of intravenously injected B16BL6-derived exosomes by macrophages
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2016.07.022
– volume: 16
  start-page: 622
  issue: 5
  year: 1968
  end-page: 626
  ident: CR35
  article-title: Cumulative illness rating scale
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.1968.tb02103.x
– volume: 23
  start-page: 1367
  issue: 9
  year: 1992
  end-page: 1379
  ident: CR46
  article-title: Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
  publication-title: Stroke
  doi: 10.1161/01.str.23.9.1367
– volume: 36
  start-page: 189
  issue: 2
  year: 2005
  end-page: 192
  ident: CR8
  article-title: Exciting, radical, suicidal: how brain cells die after stroke
  publication-title: Stroke
  doi: 10.1161/01.STR.0000153069.96296.fd
– volume: 17
  start-page: 1
  issue: 1
  year: 2017
  end-page: 8
  ident: CR34
  article-title: Validity and reliability of a performance evaluation tool based on the modified Barthel Index for stroke patients
  publication-title: BMC Med. Res. Methodol.
  doi: 10.1186/s12874-017-0409-2
– volume: 3
  start-page: 1
  year: 2012
  end-page: 6
  ident: CR26
  article-title: Microvesicles: Novel biomarkers for neurological disorders
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2012.00063
– volume: 239
  start-page: 592
  issue: 2
  year: 1997
  end-page: 597
  ident: CR50
  article-title: Intracellular location of SNAP-25 in human neutrophils
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1997.7515
– volume: 148
  year: 2021
  ident: CR32
  article-title: Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson’s disease
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2020.105185
– volume: 137
  start-page: 361
  issue: 4
  year: 2004
  end-page: 363
  ident: CR51
  article-title: Identification of exocytosis mediator proteins in peripheral blood neutrophils of patients with chronic myeloid leukemia
  publication-title: Bull. Exp. Biol. Med.
  doi: 10.1023/b:bebm.0000035130.80245.13
– volume: 95
  start-page: 254
  issue: 3
  year: 1998
  end-page: 260
  ident: CR17
  article-title: Increase in SNAP-25 immunoreactivity in the messy fibers following transient forebrain ischemia in the gerbil
  publication-title: Acta Neuropathol.
  doi: 10.1007/s004010050795
– volume: 23
  start-page: 1338
  issue: 7
  year: 2018
  end-page: 1359
  ident: CR6
  article-title: Towards precision medicine in ischemic stroke and transient ischemic attack
  publication-title: Front. Biosci.
  doi: 10.2741/4647
– volume: 20
  start-page: 1593
  issue: 6
  year: 2004
  end-page: 1603
  ident: CR48
  article-title: SNAP-25 in hippocampal CA1 region is involved in memory consolidation
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2004.03600.x
– volume: 17
  start-page: 197
  issue: 3
  year: 2010
  end-page: 218
  ident: CR1
  article-title: Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis
  publication-title: Pathophysiology
  doi: 10.1016/j.pathophys.2009.12.001
– volume: 56
  start-page: 5792
  issue: 8
  year: 2019
  end-page: 5798
  ident: CR30
  article-title: SNAP-25 in serum is carried by exosomes of neuronal origin and is a potential biomarker of alzheimer’s disease
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-019-1501-x
– volume: 8
  start-page: 309
  issue: 3
  year: 2003
  ident: 18719_CR11
  publication-title: Mol. Psychiatry.
  doi: 10.1038/sj.mp.4001247
– volume: 30
  start-page: 2174
  issue: 10
  year: 1999
  ident: 18719_CR60
  publication-title: Stroke
  doi: 10.1161/01.str.30.10.2174
– volume: 3
  start-page: 1
  year: 2012
  ident: 18719_CR23
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2012.00228
– volume: 114
  start-page: E2176
  issue: 11
  year: 2017
  ident: 18719_CR31
  publication-title: Proc. Natl. Acad Sci. USA
  doi: 10.1073/pnas.1617981114
– volume: 3
  issue: 3
  year: 2013
  ident: 18719_CR38
  publication-title: Bio-Protoc.
  doi: 10.21769/BioProtoc.323
– volume: 22
  start-page: 11
  issue: Suppl 4
  year: 2004
  ident: 18719_CR2
  publication-title: Pharmacoeconomics
  doi: 10.2165/00019053-200422004-00004
– volume: 179
  start-page: 3397
  issue: 6
  year: 2007
  ident: 18719_CR58
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.6.3397
– volume: 172
  start-page: 198
  issue: 3
  year: 2016
  ident: 18719_CR19
  publication-title: Rev. Neurol. (Paris)
  doi: 10.1016/j.neurol.2016.02.003
– volume: 11
  start-page: 1
  year: 2017
  ident: 18719_CR41
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2017.00278
– volume: 111
  start-page: 212
  issue: 2
  year: 2005
  ident: 18719_CR47
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000152105.79665.C6
– volume: 558
  start-page: 99
  issue: 1
  year: 2004
  ident: 18719_CR53
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2004.064899
– volume: 148
  year: 2021
  ident: 18719_CR32
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2020.105185
– volume: 75
  start-page: 2873
  issue: 15
  year: 2018
  ident: 18719_CR44
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-018-2773-4
– volume: 26
  start-page: 5767
  issue: 21
  year: 2006
  ident: 18719_CR49
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.0289-06.2006
– volume: 137
  start-page: 361
  issue: 4
  year: 2004
  ident: 18719_CR51
  publication-title: Bull. Exp. Biol. Med.
  doi: 10.1023/b:bebm.0000035130.80245.13
– volume: 106
  start-page: 168
  issue: 1
  year: 2017
  ident: 18719_CR22
  publication-title: J. Pharm. Sci.
  doi: 10.1016/j.xphs.2016.07.022
– volume: 23
  start-page: 1367
  issue: 9
  year: 1992
  ident: 18719_CR46
  publication-title: Stroke
  doi: 10.1161/01.str.23.9.1367
– volume: 56
  start-page: 5792
  issue: 8
  year: 2019
  ident: 18719_CR30
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-019-1501-x
– volume: 11
  start-page: 1073
  issue: 8
  year: 2008
  ident: 18719_CR12
  publication-title: Int. J. Neuropsychopharmacol.
  doi: 10.1017/S1461145708009036
– volume: 12
  start-page: 480
  issue: 5
  year: 2017
  ident: 18719_CR55
  publication-title: Int. J. Stroke.
  doi: 10.1177/1747493017714176
– volume: 31
  start-page: 642
  issue: 4
  year: 2006
  ident: 18719_CR25
  publication-title: Mol. Cell Neurosci.
  doi: 10.1016/j.mcn.2005.12.003
– volume: 54
  start-page: 498
  issue: 6
  year: 2019
  ident: 18719_CR3
  publication-title: Neuroepidemiology
  doi: 10.1159/000505160
– volume: 17
  start-page: 197
  issue: 3
  year: 2010
  ident: 18719_CR1
  publication-title: Pathophysiology
  doi: 10.1016/j.pathophys.2009.12.001
– volume: 65
  start-page: 397
  issue: 3
  year: 1999
  ident: 18719_CR28
  publication-title: J. Leukoc. Biol.
  doi: 10.1002/jlb.65.3.397
– volume: 12
  start-page: 1
  issue: 6
  year: 2017
  ident: 18719_CR40
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0179065
– volume: 61
  start-page: 346
  issue: 3
  year: 2004
  ident: 18719_CR4
  publication-title: Arch Neurol.
  doi: 10.1001/archneur.61.3.346
– ident: 18719_CR43
– volume: 239
  start-page: 592
  issue: 2
  year: 1997
  ident: 18719_CR50
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.1997.7515
– volume: 12
  start-page: 444
  issue: 5
  year: 2017
  ident: 18719_CR54
  publication-title: Int. J Stroke.
  doi: 10.1177/1747493017711816
– volume: 47
  start-page: 260
  issue: 3
  year: 2009
  ident: 18719_CR18
  publication-title: J. Pineal Res.
  doi: 10.1111/j.1600-079X.2009.00709.x
– volume: 14
  start-page: 1
  year: 2020
  ident: 18719_CR10
  publication-title: Front. Cell Neurosci.
  doi: 10.3389/fncel.2020.00051
– volume: 61
  start-page: 548
  issue: 5
  year: 2018
  ident: 18719_CR20
  publication-title: J. Korean Neurosurg. Soc.
  doi: 10.3340/jkns.2017.0200
– volume: 42
  start-page: 470
  issue: 2
  year: 2012
  ident: 18719_CR29
  publication-title: Eur. J. Immunol.
  doi: 10.1002/eji.201141915
– volume: 17
  start-page: 160
  issue: 3
  year: 2016
  ident: 18719_CR61
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2015.29
– volume: 36
  start-page: 189
  issue: 2
  year: 2005
  ident: 18719_CR8
  publication-title: Stroke
  doi: 10.1161/01.STR.0000153069.96296.fd
– volume: 126
  start-page: 1190
  issue: 4
  year: 2016
  ident: 18719_CR45
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI81133
– volume: 7
  start-page: 1
  issue: 1
  year: 2017
  ident: 18719_CR14
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-04017-9
– volume: 12
  start-page: 189
  issue: 3
  year: 1975
  ident: 18719_CR36
  publication-title: J. Psychiatr. Res.
  doi: 10.1016/0022-3956(75)90026-6
– volume: 17
  start-page: 1
  issue: 1
  year: 2017
  ident: 18719_CR34
  publication-title: BMC Med. Res. Methodol.
  doi: 10.1186/s12874-017-0409-2
– volume: 15
  start-page: 748
  issue: 7
  year: 2010
  ident: 18719_CR13
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2008.148
– volume: 16
  start-page: 622
  issue: 5
  year: 1968
  ident: 18719_CR35
  publication-title: J. Am. Geriatr. Soc.
  doi: 10.1111/j.1532-5415.1968.tb02103.x
– volume: 5
  issue: 10
  year: 2019
  ident: 18719_CR59
  publication-title: Heliyon
  doi: 10.1016/j.heliyon.2019.e02590
– volume: 20
  start-page: 1593
  issue: 6
  year: 2004
  ident: 18719_CR48
  publication-title: Eur. J. Neurosci.
  doi: 10.1111/j.1460-9568.2004.03600.x
– volume: 55
  start-page: 952
  issue: 7
  year: 2000
  ident: 18719_CR63
  publication-title: Neurology
  doi: 10.1212/wnl.55.7.952
– volume: 59
  start-page: 62
  issue: 1
  year: 2020
  ident: 18719_CR62
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.23129
– volume: 23
  start-page: 1338
  issue: 7
  year: 2018
  ident: 18719_CR6
  publication-title: Front. Biosci.
  doi: 10.2741/4647
– volume: 82
  start-page: 1088
  issue: 5
  year: 2014
  ident: 18719_CR15
  publication-title: Neuron
  doi: 10.1016/j.neuron.2014.04.020
– volume: 95
  start-page: 254
  issue: 3
  year: 1998
  ident: 18719_CR17
  publication-title: Acta Neuropathol.
  doi: 10.1007/s004010050795
– volume: 53
  start-page: 126
  issue: 1
  year: 1999
  ident: 18719_CR33
  publication-title: Neurology
  doi: 10.1212/wnl.53.1.126
– volume: 93
  start-page: 2617
  issue: 8
  year: 1999
  ident: 18719_CR52
  publication-title: Blood
  doi: 10.1182/blood.V93.8.2617
– volume: 7
  start-page: 40
  issue: 1
  year: 2015
  ident: 18719_CR21
  publication-title: Alzheimers Res. Ther.
  doi: 10.1186/s13195-015-0124-3
– volume: 6
  start-page: 860
  issue: 7
  year: 2018
  ident: 18719_CR42
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-17-0604
– volume: 31
  start-page: 77
  issue: 1
  year: 2000
  ident: 18719_CR5
  publication-title: Stroke
  doi: 10.1161/01.str.31.1.77
– volume: 1
  start-page: 261
  issue: 3
  year: 1994
  ident: 18719_CR56
  publication-title: Clin. Diagn. Lab Immunol.
  doi: 10.1128/cdli.1.3.261-268.1994
– volume: 3
  start-page: 1
  year: 2012
  ident: 18719_CR26
  publication-title: Front. Physiol.
  doi: 10.3389/fphys.2012.00063
– volume: 30
  start-page: 255
  issue: 1
  year: 2014
  ident: 18719_CR24
  publication-title: Annu. Rev. Cell Dev. Biol.
  doi: 10.1146/annurev-cellbio-101512-122326
– volume: 27
  start-page: 2712
  issue: 13
  year: 2006
  ident: 18719_CR39
  publication-title: Electrophoresis
  doi: 10.1002/elps.200500964
– volume: 1
  start-page: 99
  issue: 1
  year: 2012
  ident: 18719_CR37
  publication-title: Am. J. Neurodegener. Dis.
– volume: 12
  start-page: 723
  issue: 6
  year: 1981
  ident: 18719_CR7
  publication-title: Stroke
  doi: 10.1161/01.str.12.6.723
– volume: 1272
  start-page: 52
  year: 2009
  ident: 18719_CR16
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2009.03.047
– volume: 15
  start-page: 5399
  year: 2004
  ident: 18719_CR57
  publication-title: Mol. Biol. Cell.
  doi: 10.1091/mbc.e04-03-0182
– volume: 7
  start-page: 74537
  issue: 46
  year: 2016
  ident: 18719_CR27
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12902
– volume: 1802
  start-page: 80
  issue: 1
  year: 2010
  ident: 18719_CR9
  publication-title: Biochim. Biophys. Acta.
  doi: 10.1016/j.bbadis.2009.09.003
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Snippet The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their identification in...
Abstract The interest for the discovery of blood biomarkers for several neurological disorders, including Ischemic Stroke (IS), is growing and their...
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StartPage 14483
SubjectTerms 631/378
631/45
Biomarkers
Blood flow
Blood levels
Blood-brain barrier
Brain injury
Cerebral blood flow
Cytoplasm
Extracellular vesicles
Humanities and Social Sciences
Ischemia
Membrane permeability
multidisciplinary
Neurological diseases
Patients
Peripheral blood mononuclear cells
Science
Science (multidisciplinary)
SNAP-25 protein
Stroke
Syntaxin
Syntaxin 1
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Title Syntaxin-1a and SNAP-25 expression level is increased in the blood samples of ischemic stroke patients
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Volume 12
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