Potential effects of allyl isothiocyanate on inhibiting cellular proliferation and inducing apoptotic pathway in human cisplatin-resistant oral cancer cells

• Published in: Journal of the Formosan Medical Association Vol. 120; no. 1; pp. 515 - 523
• Main Authors: Chang, Pei-ying, Tsai, Fuu-jen, Bau, Da-tian, Hsu, Yuan-man, Yang, Jai-sing, Tu, Ming-gene, Chiang, Shang-lun
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01.01.2021; Elsevier
• Subjects: AITC; Apoptosis; CAR cells; Cell Line, Tumor; Cell Proliferation; Cisplatin - pharmacology; Cisplatin resistance; Drug Resistance, Neoplasm; Humans; Isothiocyanates; Mouth Neoplasms - drug therapy; OSCC; OSCC; AITC; Cisplatin resistance; CAR cells; Apoptosis

Cisplatin-resistant oral cancer is clinically difficult to manage and the dose-dependent toxicities of cisplatin has been widely concerned. Allyl isothiocyanate (AITC), known as mustard oil, is a plant-derived compound abundant in cruciferous vegetables. It is reported to have anti-cancer potential...