Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness

• Published in: Current biology Vol. 26; no. 9; pp. 1138 - 1147
• Main Authors: Cerulus, Bram, New, Aaron M., Pougach, Ksenia, Verstrepen, Kevin J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 09.05.2016
• Subjects: Cell Division - physiology; Epigenesis, Genetic - physiology; Gene Expression Regulation, Fungal - physiology; Genetic Fitness; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - physiology; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Time Factors

The fitness effect of biological noise remains unclear. For example, even within clonal microbial populations, individual cells grow at different speeds. Although it is known that the individuals’ mean growth speed can affect population-level fitness, it is unclear how or whether growth speed hetero...