Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

• Published in: Cancer cell Vol. 21; no. 4; pp. 504 - 516
• Main Authors: Dapito, Dianne H., Mencin, Ali, Gwak, Geum-Youn, Pradere, Jean-Philippe, Jang, Myoung-Kuk, Mederacke, Ingmar, Caviglia, Jorge M., Khiabanian, Hossein, Adeyemi, Adebowale, Bataller, Ramon, Lefkowitch, Jay H., Bower, Maureen, Friedman, Richard, Sartor, R. Balfour, Rabadan, Raul, Schwabe, Robert F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 17.04.2012
• Subjects: Animals; Apoptosis - genetics; Bacterial Translocation; Cell Proliferation; Epidermal Growth Factor - metabolism; Epiregulin; Humans; Intestines - microbiology; Liver Diseases - complications; Liver Diseases - microbiology; Liver Neoplasms, Experimental - genetics; Liver Neoplasms, Experimental - microbiology; Liver Neoplasms, Experimental - pathology; Mice; Mice, Inbred C57BL; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - physiology; Tumor Cells, Cultured

Increased translocation of intestinal bacteria is a hallmark of chronic liver disease and contributes to hepatic inflammation and fibrosis. Here we tested the hypothesis that the intestinal microbiota and Toll-like receptors (TLRs) promote hepatocellular carcinoma (HCC), a long-term consequence of c...