Fabrication of high-quality glass microfluidic devices for bioanalytical and space flight applications
Microfabricated glass microfluidic and Capillary Electrophoresis (CE) devices have been utilized in a wide variety of applications over the past thirty years. At the Berkeley Space Sciences Laboratory, we are working to further expand this technology by developing analytical instruments to chemicall...
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Published in | MethodsX Vol. 7; p. 101043 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.01.2020
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Abstract | Microfabricated glass microfluidic and Capillary Electrophoresis (CE) devices have been utilized in a wide variety of applications over the past thirty years. At the Berkeley Space Sciences Laboratory, we are working to further expand this technology by developing analytical instruments to chemically explore our solar system. This effort requires improving the quality and reliability of glass microfabrication through quality control procedures at every stage of design and manufacture. This manuscript provides detailed information on microfabrication technology for the production of high-quality glass microfluidic chips in compliance with industrial standards and space flight instrumentation quality control.•The methodological protocol provided in this paper includes the scope of each step of the manufacturing process, materials and technologies recommended and the specific challenges that often confront the process developer.•Types and sources of fabrication error at every stage have been identified and their solutions have been proposed and verified.•We present robust and rigorous manufacturing and quality control procedures that will assist other researchers in achieving the highest possible quality glass microdevices using the latest apparatus in a routine and reliable fashion.
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AbstractList | Microfabricated glass microfluidic and Capillary Electrophoresis (CE) devices have been utilized in a wide variety of applications over the past thirty years. At the Berkeley Space Sciences Laboratory, we are working to further expand this technology by developing analytical instruments to chemically explore our solar system. This effort requires improving the quality and reliability of glass microfabrication through quality control procedures at every stage of design and manufacture. This manuscript provides detailed information on microfabrication technology for the production of high-quality glass microfluidic chips in compliance with industrial standards and space flight instrumentation quality control. • The methodological protocol provided in this paper includes the scope of each step of the manufacturing process, materials and technologies recommended and the specific challenges that often confront the process developer. • Types and sources of fabrication error at every stage have been identified and their solutions have been proposed and verified. • We present robust and rigorous manufacturing and quality control procedures that will assist other researchers in achieving the highest possible quality glass microdevices using the latest apparatus in a routine and reliable fashion. Microfabricated glass microfluidic and Capillary Electrophoresis (CE) devices have been utilized in a wide variety of applications over the past thirty years. At the Berkeley Space Sciences Laboratory, we are working to further expand this technology by developing analytical instruments to chemically explore our solar system. This effort requires improving the quality and reliability of glass microfabrication through quality control procedures at every stage of design and manufacture. This manuscript provides detailed information on microfabrication technology for the production of high-quality glass microfluidic chips in compliance with industrial standards and space flight instrumentation quality control.•The methodological protocol provided in this paper includes the scope of each step of the manufacturing process, materials and technologies recommended and the specific challenges that often confront the process developer.•Types and sources of fabrication error at every stage have been identified and their solutions have been proposed and verified.•We present robust and rigorous manufacturing and quality control procedures that will assist other researchers in achieving the highest possible quality glass microdevices using the latest apparatus in a routine and reliable fashion. [Display omitted] Microfabricated glass microfluidic and Capillary Electrophoresis (CE) devices have been utilized in a wide variety of applications over the past thirty years. At the Berkeley Space Sciences Laboratory, we are working to further expand this technology by developing analytical instruments to chemically explore our solar system. This effort requires improving the quality and reliability of glass microfabrication through quality control procedures at every stage of design and manufacture. This manuscript provides detailed information on microfabrication technology for the production of high-quality glass microfluidic chips in compliance with industrial standards and space flight instrumentation quality control. • The methodological protocol provided in this paper includes the scope of each step of the manufacturing process, materials and technologies recommended and the specific challenges that often confront the process developer. • Types and sources of fabrication error at every stage have been identified and their solutions have been proposed and verified. • We present robust and rigorous manufacturing and quality control procedures that will assist other researchers in achieving the highest possible quality glass microdevices using the latest apparatus in a routine and reliable fashion. Image, graphical abstract |
ArticleNumber | 101043 |
Author | Mathies, Richard A. Casto, Laura D. McCauley, Jeremy Golozar, Matin Butterworth, Anna L. Chu, Wai K. |
Author_xml | – sequence: 1 givenname: Matin orcidid: 0000-0003-1133-1588 surname: Golozar fullname: Golozar, Matin email: matin.golozar@berkeley.edu organization: Department of Chemistry and Biophysics Graduate Group, University of California, Berkeley, CA 94720, United States – sequence: 2 givenname: Wai K. surname: Chu fullname: Chu, Wai K. organization: Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States – sequence: 3 givenname: Laura D. surname: Casto fullname: Casto, Laura D. organization: Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720, United States – sequence: 4 givenname: Jeremy surname: McCauley fullname: McCauley, Jeremy organization: Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720, United States – sequence: 5 givenname: Anna L. surname: Butterworth fullname: Butterworth, Anna L. organization: Space Sciences Laboratory, University of California, 7 Gauss Way, Berkeley, CA 94720, United States – sequence: 6 givenname: Richard A. surname: Mathies fullname: Mathies, Richard A. organization: Department of Chemistry and Biophysics Graduate Group, University of California, Berkeley, CA 94720, United States |
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Keywords | Fabrication technology for the production of high-quality glass microfluidic chips Lab-on-a-chip Glass microfabrication Capillary electrophoresis Biosignature detection Astrobiology |
Language | English |
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SubjectTerms | Astrobiology Biosignature detection Capillary electrophoresis Glass microfabrication Lab-on-a-chip Method |
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Title | Fabrication of high-quality glass microfluidic devices for bioanalytical and space flight applications |
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