Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells

• Published in: International journal of environmental research and public health Vol. 13; no. 1; pp. 17 - ijerph13010017
• Main Authors: Schexnayder, Chandler, Stratford, Robert
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.12.2015; MDPI
• Subjects: ATP-Binding Cassette Transporters - drug effects; Breast cancer; Caco-2 Cells - drug effects; Cells; Estrogens; Flavonoids; Genistein - pharmacology; Humans; Intestines - drug effects; Multidrug Resistance-Associated Proteins - drug effects; Neoplasm Proteins - drug effects; Pterocarpans - pharmacology; BCRP; phytoestrogen; MRP2; genistein; glyceollin; drug-food interaction; isoflavonoids

The goal of the present study was to determine the effects of glyceollins on intestinal ABCC2 (ATP Binding Cassette C2, multidrug resistance protein 2, MRP2) and ABCG2 (ATP Binding Cassette G2, breast cancer resistance protein, BCRP) function using the Caco-2 cell intestinal epithelial cell model. G...