Detection, identification, and quantification of oxidative protein modifications

• Published in: The Journal of biological chemistry Vol. 294; no. 51; pp. 19683 - 19708
• Main Authors: Hawkins, Clare L., Davies, Michael J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.12.2019; American Society for Biochemistry and Molecular Biology
• Subjects: Amino Acids - metabolism; Animals; Anions; Antioxidants - chemistry; carbonyl; disulfide; Free Radicals; Humans; hydroperoxide; JBC Reviews; Kinetics; Nitric Oxide - chemistry; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen - chemistry; oxygen radicals; Peptides - metabolism; post-translational modification; protein chemical modification; protein cross-linking; Protein Processing, Post-Translational; Proteins - metabolism; Reactive Oxygen Species; Ultraviolet Rays; carbonyl; disulfide; protein chemical modification; reactive oxygen species; hydroperoxide; post-translational modification; oxygen radicals; oxidative stress; protein cross-linking

Exposure of biological molecules to oxidants is inevitable and therefore commonplace. Oxidative stress in cells arises from both external agents and endogenous processes that generate reactive species, either purposely (e.g. during pathogen killing or enzymatic reactions) or accidentally (e.g. expos...