Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation

Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysi...

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Published inPharmacology, biochemistry and behavior Vol. 189; p. 172856
Main Authors Gilbert, Jessica R., Zarate, Carlos A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2020
Subjects
Animals
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Biomarkers
Depressive Disorder, Treatment-Resistant - drug therapy
Dynamic causal modeling
Electrophysiology
Gamma
Gamma Rhythm - drug effects
Humans
Ketamine
Ketamine - pharmacology
Ketamine - therapeutic use
Long-term potentiation
Long-Term Potentiation - drug effects
Synaptic Potentials - drug effects
Electrophysiology
Gamma
Ketamine
Dynamic causal modeling
Long-term potentiation
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Abstract Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using novel computational modeling techniques, in particular the application of dynamic causal modeling to electrophysiological data. The latter promises to better characterize the mechanisms underlying ketamine's antidepressant effects. •Electrophysiological studies of ketamine's effects are reviewed.•Review includes ketamine response in depression and healthy subjects.•Markers of synaptic potentiation reviewed include gamma and long-term potentiation.•Dynamic causal modeling of ketamine response is discussed.
AbstractList Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using novel computational modeling techniques, in particular the application of dynamic causal modeling to electrophysiological data. The latter promises to better characterize the mechanisms underlying ketamine's antidepressant effects.
Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using novel computational modeling techniques, in particular the application of dynamic causal modeling to electrophysiological data. The latter promises to better characterize the mechanisms underlying ketamine's antidepressant effects. •Electrophysiological studies of ketamine's effects are reviewed.•Review includes ketamine response in depression and healthy subjects.•Markers of synaptic potentiation reviewed include gamma and long-term potentiation.•Dynamic causal modeling of ketamine response is discussed.
Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using novel computational modeling techniques, in particular the application of dynamic causal modeling to electrophysiological data. The latter promises to better characterize the mechanisms underlying ketamine's antidepressant effects.Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant depression. Nevertheless, the mechanism of action underlying antidepressant response to ketamine remains unclear. This study reviews electrophysiological studies of ketamine's effects in individuals with depression as well as healthy controls, with a focus on two putative markers of synaptic potentiation: gamma oscillations and long-term potentiation. The review focuses on: 1) measures of gamma oscillations and power and their relationship to both acute, psychotomimetic drug effects as well as delayed antidepressant response in mood disorders; 2) changes in long-term potentiation as a promising measure of synaptic potentiation following ketamine administration; and 3) recent efforts to model antidepressant response to ketamine using novel computational modeling techniques, in particular the application of dynamic causal modeling to electrophysiological data. The latter promises to better characterize the mechanisms underlying ketamine's antidepressant effects.
ArticleNumber 172856
Author Zarate, Carlos A.
Gilbert, Jessica R.
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Keywords Electrophysiology
Gamma
Ketamine
Dynamic causal modeling
Long-term potentiation
Language English
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Snippet Over the last two decades, the discovery of ketamine's antidepressant properties has galvanized research into the neurobiology of treatment-resistant...
Over the last two decades, the discovery of ketamine’s antidepressant properties has galvanized research into the neurobiology of treatment-resistant...
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SubjectTerms Animals
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Biomarkers
Depressive Disorder, Treatment-Resistant - drug therapy
Dynamic causal modeling
Electrophysiology
Gamma
Gamma Rhythm - drug effects
Humans
Ketamine
Ketamine - pharmacology
Ketamine - therapeutic use
Long-term potentiation
Long-Term Potentiation - drug effects
Synaptic Potentials - drug effects
Title Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation
URI https://dx.doi.org/10.1016/j.pbb.2020.172856
https://www.ncbi.nlm.nih.gov/pubmed/31958471
https://www.proquest.com/docview/2343040386
https://pubmed.ncbi.nlm.nih.gov/PMC6997043
Volume 189
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