Inflammatory vasculopathy in multifocal diabetic neuropathy

• Published in: Brain (London, England : 1878) Vol. 126; no. 2; pp. 376 - 385
• Main Authors: Said, Gérard, Lacroix, Catherine, Lozeron, Pierre, Ropert, Angèle, Planté, Violaine, Adams, David
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.02.2003; Oxford Publishing Limited (England)
• Subjects: Action Potentials; Adult; Aged; Aged, 80 and over; Associated diseases and complications; Biological and medical sciences; Biopsy; Capillaries - ultrastructure; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - complications; Diabetic Angiopathies - pathology; Diabetic Angiopathies - physiopathology; Diabetic Neuropathies - complications; Diabetic Neuropathies - pathology; Diabetic Neuropathies - physiopathology; diabetic neuropathy; DSP = distal symmetrical polyneuropathy; Electrophysiology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Follow-Up Studies; Hemorrhage - complications; Hemorrhage - pathology; Humans; Male; MDN = multifocal diabetic neuropathy; Medical sciences; Middle Aged; multifocal diabetic neuropathy; nerve biopsy; Nerve Fibers - pathology; PDN = proximal diabetic neuropathy; Peripheral Nerves - blood supply; Peripheral Nerves - ultrastructure; Peripheral Nervous System Diseases - complications; Peripheral Nervous System Diseases - pathology; Prospective Studies; vasculitic neuropathy; Vasculitis - complications; Vasculitis - pathology; Vasculitis - physiopathology; Endocrinopathy; Human; Nervous system diseases; Pathogenesis; diabetic neuropathy; Diabetes mellitus; nerve biopsy; Clinical form; Sensorimotor peripheral polyneuropathy; Blood vessel; Complication; Circulatory system; Peripheral nerve disease; multifocal diabetic neuropathy; vasculitic neuropathy; Comparative study; Symmetry

Besides the common distal symmetrical sensory–motor polyneuropathy (DSP) that is often associated with autonomic dysfunction, diabetic patients may develop multifocal sensory–motor deficits (MDN) secondary to roots, plexus and nerve trunk involvement. Nerve ischaemia has been suggested as a common m...