LncRNA-mRNA co-expression network in the mechanism of butylphthalide treatment for ischemic stroke

• Published in: BMC neurology Vol. 25; no. 1; pp. 155 - 12
• Main Authors: An, Yangfang, Huang, Lingyun, Li, Jun, Chen, Zhuo, Cai, Jizhang, Wang, Biao, Zhou, Qiong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.04.2025; BioMed Central; BMC
• Subjects: Aged; Angiogenesis; Benzofurans - pharmacology; Benzofurans - therapeutic use; Butylphthalide; Cell cycle; Cell migration; Cell proliferation; Cellular signal transduction; DNA microarrays; Down-regulation; Drug therapy; Embryogenesis; Embryonic development; Energy metabolism; Female; Gene expression; Gene Regulatory Networks - drug effects; Genes; Genetic aspects; Genomics; Glucose metabolism; Health aspects; Humans; Inflammation; Ischemia; Ischemic stroke; Ischemic Stroke - drug therapy; Ischemic Stroke - genetics; LncRNA-mRNA co-expression network; Male; Messenger RNA; Middle Aged; Molecular Docking Simulation; Mortality; mRNA; Neural networks; Neurological research; Neuroprotective agents; Non-coding RNA; Peripheral blood; Physiological aspects; Protein interaction; Protein Interaction Maps - drug effects; Protein-protein interactions; Proteins; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-seq; Signal transduction; Software; Statistical analysis; Stroke; Stroke (Disease); Therapeutic targets; China; LncRNA-mRNA co-expression network; Ischemic stroke; RNA-seq; Butylphthalide

Butylphthalide has shown significant potential in the treatment of ischemic stroke, but its precise mechanisms of action remain unclear. Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in the pathogenesis of ischemic stroke and may serve as potential therapeutic targets....