Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells

• Published in: Nature communications Vol. 12; no. 1; pp. 3789 - 15
• Main Authors: Miyauchi, Kosuke, Adachi, Yu, Tonouchi, Keisuke, Yajima, Taiki, Harada, Yasuyo, Fukuyama, Hidehiro, Deno, Senka, Iwakura, Yoichiro, Yoshimura, Akihiko, Hasegawa, Hideki, Yugi, Katsuyuki, Fujii, Shin-ichiro, Ohara, Osamu, Takahashi, Yoshimasa, Kubo, Masato
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/31; 38/23; 631/250/127/1213; 631/250/1619/40; 631/250/2152/2153/1291; 631/326/596/1578; Antibodies; Antibody response; Cell proliferation; Epitopes; Hemagglutinins; Humanities and Social Sciences; Immune system; Immunoglobulin G; Infections; Influenza; Interleukin 4; Lymphocytes; Lymphocytes B; Lymphocytes T; multidisciplinary; Public health; Science; Science (multidisciplinary); Sinusitis; Vaccines; Viruses

Influenza viruses are a major public health problem. Vaccines are the best available countermeasure to induce effective immunity against infection with seasonal influenza viruses; however, the breadth of antibody responses in infection versus vaccination is quite different. Here, we show that nasal...