Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis

• Published in: Neoplasia (New York, N.Y.) Vol. 21; no. 7; pp. 641 - 652
• Main Authors: Chen, Tsai-Ying, Hsieh, Yi-Ta, Huang, Jian-Min, Liu, Chung-Ji, Chuang, Lu-Te, Huang, Pei-Chun, Kuo, Tz-Yu, Chia, Hao-Yuan, Chou, Chia-Yi, Chang, Ching-Wen, Chen, Yi-Fen, Chen, Hsin-Ming, Lo, Jeng-Fan, Li, Wan-Chun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2019; Neoplasia Press; Elsevier
• Subjects: Animals; Carcinogenesis - genetics; Cell Line, Tumor; Cell Proliferation - genetics; Glycolysis - genetics; Heterografts; Humans; L-Lactate Dehydrogenase - genetics; Lactic Acid - metabolism; Mice; Mitochondria - genetics; Original article; Pyruvate Dehydrogenase (Lipoamide) - genetics; Pyruvic Acid - metabolism; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; G3PDH; OxPhos; MTT; Gluts; MUFAs; shRNA; TAXOL; IC50; PFK1; DLAT; SCD1; GC-FID; PDK1; 4-NQO; DON; DCA; PKB/Akt; EGCG; PGAM1; EMT; TCGA; CDDP; NHOK; TCA; HNSCC; ROS; DLD; ERK; ABC; GLS1; SFAs; ENO; INN; SREBF1/2; ACACB; PDC; PPP; LDHA; PDHA1; OS; PKM2; LC–MS; ECM; PDP1; ALDH; hOSCC; FASN; GLUD1/2; PEP; PUFAs; 5-FU; OCR

Even with increasing evidence for roles of glycolytic enzymes in controlling cancerous characteristics, the best target of candidate metabolic enzymes for lessening malignancy remains under debate. Pyruvate is a main glycolytic metabolite that could be mainly converted into either lactate by Lactate...