Spike ripples in striatum correlate with seizure risk in two mouse models

• Published in: Epilepsy & behavior reports Vol. 18; p. 100529
• Main Authors: Shi, Wen, Zemel, Dana, Sridhar, Sudiksha, Mount, Rebecca A., Richardson, R. Mark, Eden, Uri T., Han, Xue, Kramer, Mark A., Chu, Catherine J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2022; Elsevier
• Subjects: Basal ganglia; EEG biomarker; Epilepsy; HFOs; IEDs; Spike-ripple; HFO; Basal ganglia; HFOs; Spike-ripple; EEG biomarker; Epilepsy; EEG; LFP; IEDs; 6-OHDA; HFO, high frequency oscillation; 6-OHDA, 6-hydroxydopamine; EEG, electroencephalogram; LFP, local field potential

•We recorded electrographic seizures in the striatum in two rodent models.•We identified spike ripples in rodent striatum with similar features as observed in human hippocampus and cerebral cortex.•Spike ripple rate was increased in the post-infusion ictal and interictal periods compared to pre-infu...