Glutamate cysteine ligase catalytic subunit promoter polymorphisms and associations with type 1 diabetes age-at-onset and GAD65 autoantibody levels

• Published in: Experimental and clinical endocrinology & diabetes Vol. 115; no. 4; p. 221
• Main Authors: Bekris, L M, Shephard, C, Janer, M, Graham, J, McNeney, B, Shin, J, Zarghami, M, Griffith, W, Farin, F, Kavanagh, T J, Lernmark, A
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2007
• Subjects: Adolescent; Adult; Age of Onset; Autoantibodies - blood; Child; Child, Preschool; Diabetes Mellitus, Type 1 - genetics; Female; Genotype; Glutamate Decarboxylase - immunology; Glutamate-Cysteine Ligase - genetics; Humans; Infant; Isoenzymes - immunology; Male; Polymorphism, Genetic; Promoter Regions, Genetic

The purpose of this study was to test the hypothesis that glutamate cysteine ligase catalytic subunit (GCLC) promoter polymorphisms are susceptibility factors for type 1 diabetes (T1D), T1D age-at-onset and T1D autoantibodies. T1D patients and control subjects from the Swedish Childhood Diabetes Reg...