Predictive accuracy of fecal calprotectin in assessing clinical activity and disease severity in patients with Ulcerative Colitis and Crohn’s disease

• Published in: BMC gastroenterology Vol. 25; no. 1; pp. 429 - 9
• Main Authors: Jain, Ankit V., Gopal, Sandeep, Shetty, Anurag J., Shenoy, Suresh, Tantry, B. V., Unnikrishnan, B., Holla, Ramesh, Anand, Rishit
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.06.2025; BioMed Central; BMC
• Subjects: Adolescent; Adult; Age groups; Biomarkers - analysis; Blood; Calcium-binding proteins; Care and treatment; Colitis; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Colonoscopy; Crohn disease; Crohn Disease - diagnosis; Crohn Disease - metabolism; Crohn Disease - pathology; Crohn's disease; Diagnosis; Endoscopy; Fecal calprotectin; Feces; Feces - chemistry; Female; Gastrointestinal diseases; Health aspects; Humans; IBD; Infections; Inflammatory bowel disease; Inflammatory bowel diseases; Leukocyte L1 Antigen Complex - analysis; Male; Measurement; Medical examination; Medical research; Medicine, Experimental; Middle Aged; Patients; Predictive Value of Tests; Recurrence; Remission; Remission (Medicine); Sensitivity and Specificity; Severity of Illness Index; Statistical analysis; Ulcerative colitis; Young Adult; India; Fecal calprotectin; Crohn disease; IBD; Ulcerative colitis
• ISSN: 1471-230X; 1471-230X
• DOI: 10.1186/s12876-025-04035-2

Inflammatory bowel disease (IBD) is an idiopathic disorder characterized by repeated relapses and remissions. Endoscopy, the gold standard for diagnosis and monitoring of these patients is time consuming, expensive, and invasive. Hence, faecal calprotectin (FCP) has been suggested as marker to deter...