Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and...

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Published inNanotoxicology Vol. 6; no. 7; pp. 746 - 756
Main Authors Li, Ching-Hao, Shen, Chuan-Chou, Cheng, Yu-Wen, Huang, Shih-Hsuan, Wu, Chung-Che, Kao, Chen-Chieh, Liao, Jiunn-Wang, Kang, Jaw-Jou
Format Journal Article
LanguageEnglish
Published England Informa UK, Ltd 01.11.2012
Taylor & Francis
Subjects
Absorption
Administration, Oral
Analysis of Variance
Animals
biodistribution
Cell Survival - drug effects
clearance
Cytotoxicity
Female
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - drug effects
Humans
Hydrogen-Ion Concentration
Injections, Intraperitoneal
Kidney - chemistry
Kidney - metabolism
Liver - chemistry
Liver - metabolism
Male
Mice
Mice, Inbred ICR
Micronucleus Tests
nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - toxicity
Particle Size
Solubility
Spleen - chemistry
Spleen - metabolism
Superoxides - metabolism
Tissue Distribution
Toxicity Tests, Acute
Zinc oxide
Zinc Oxide - administration & dosage
Zinc Oxide - pharmacokinetics
Zinc Oxide - toxicity
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Abstract Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
AbstractList Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 mu g/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
Author Kao, Chen-Chieh
Huang, Shih-Hsuan
Li, Ching-Hao
Kang, Jaw-Jou
Cheng, Yu-Wen
Liao, Jiunn-Wang
Shen, Chuan-Chou
Wu, Chung-Che
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– sequence: 2
  givenname: Chuan-Chou
  surname: Shen
  fullname: Shen, Chuan-Chou
  email: jjkang@, jjkang@
  organization: Department of Geosciences
– sequence: 3
  givenname: Yu-Wen
  surname: Cheng
  fullname: Cheng, Yu-Wen
  email: jjkang@, jjkang@
  organization: 1 Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan
– sequence: 4
  givenname: Shih-Hsuan
  surname: Huang
  fullname: Huang, Shih-Hsuan
  email: jjkang@, jjkang@
  organization: Institute of Toxicology
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  givenname: Chung-Che
  surname: Wu
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  surname: Kao
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– sequence: 7
  givenname: Jiunn-Wang
  surname: Liao
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  email: jjkang@, jjkang@
  organization: Graduate Institute of Veterinary Pathology
– sequence: 8
  givenname: Jaw-Jou
  surname: Kang
  fullname: Kang, Jaw-Jou
  email: jjkang@, jjkang@
  organization: Institute of Toxicology
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21950449$$D View this record in MEDLINE/PubMed
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PublicationTitle Nanotoxicology
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Taylor & Francis
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Hackenberg S (CIT0007) 2011; 25
Matsumura M (CIT0018) 2010; 7
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Karlsson HL (CIT0011) 2010; 398
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Fröhlich E (CIT0004) 2009; 34
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Snippet Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and...
Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally...
Abstract Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and...
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SubjectTerms Absorption
Administration, Oral
Analysis of Variance
Animals
biodistribution
Cell Survival - drug effects
clearance
Cytotoxicity
Female
Human Umbilical Vein Endothelial Cells - cytology
Human Umbilical Vein Endothelial Cells - drug effects
Humans
Hydrogen-Ion Concentration
Injections, Intraperitoneal
Kidney - chemistry
Kidney - metabolism
Liver - chemistry
Liver - metabolism
Male
Mice
Mice, Inbred ICR
Micronucleus Tests
nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - toxicity
Particle Size
Solubility
Spleen - chemistry
Spleen - metabolism
Superoxides - metabolism
Tissue Distribution
Toxicity Tests, Acute
Zinc oxide
Zinc Oxide - administration & dosage
Zinc Oxide - pharmacokinetics
Zinc Oxide - toxicity
Title Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice
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