Escherichia coli urinary tract infections: Host age-related differences in bacterial virulence factors and antimicrobial susceptibility
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial vir...
Saved in:
| Published in | Journal of microbiology, immunology and infection Vol. 55; no. 2; pp. 249 - 256 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier B.V
01.04.2022
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1684-1182 1995-9133 1995-9133 |
| DOI | 10.1016/j.jmii.2021.04.001 |
Cover
Loading…
| Abstract | Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial virulence factors and antimicrobial susceptibility.
PCRs were carried out to detect K1 capsule antigen, 15 virulence factors, and phylogenetic groups in E. coli isolates. Antimicrobial susceptibility of selected agents was determined by the disk diffusion method. Isolates were divided into 6 groups based on their host age.
The results showed that virulence factors PapGII, PapGIII, Cnf1, Aer, Usp, Iha, OmpT, HlyA, and Sat, had highest frequencies in the host age group 0–3. Phylogenetic group B2 dominated in our isolates (59.6%) followed by group D (20.7%). In addition, 77.4% of strains isolated from 0 to 3 age group belonged to phylogenetic group B2. Antimicrobial susceptibility tests showed that E. coli strains isolated were significantly more resistant to antimicrobial agents as host age increased. Phylogenetic group B2 isolates were more susceptible to antimicrobial agents, compared to A, B1, and D isolates.
We found E. coli isolated from elders were more resistant to antimicrobial agents and had less virulence factors. |
|---|---|
| AbstractList | Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial virulence factors and antimicrobial susceptibility.
PCRs were carried out to detect K1 capsule antigen, 15 virulence factors, and phylogenetic groups in E. coli isolates. Antimicrobial susceptibility of selected agents was determined by the disk diffusion method. Isolates were divided into 6 groups based on their host age.
The results showed that virulence factors PapGII, PapGIII, Cnf1, Aer, Usp, Iha, OmpT, HlyA, and Sat, had highest frequencies in the host age group 0-3. Phylogenetic group B2 dominated in our isolates (59.6%) followed by group D (20.7%). In addition, 77.4% of strains isolated from 0 to 3 age group belonged to phylogenetic group B2. Antimicrobial susceptibility tests showed that E. coli strains isolated were significantly more resistant to antimicrobial agents as host age increased. Phylogenetic group B2 isolates were more susceptible to antimicrobial agents, compared to A, B1, and D isolates.
We found E. coli isolated from elders were more resistant to antimicrobial agents and had less virulence factors. Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial virulence factors and antimicrobial susceptibility.BACKGROUNDUrinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial virulence factors and antimicrobial susceptibility.PCRs were carried out to detect K1 capsule antigen, 15 virulence factors, and phylogenetic groups in E. coli isolates. Antimicrobial susceptibility of selected agents was determined by the disk diffusion method. Isolates were divided into 6 groups based on their host age.METHODSPCRs were carried out to detect K1 capsule antigen, 15 virulence factors, and phylogenetic groups in E. coli isolates. Antimicrobial susceptibility of selected agents was determined by the disk diffusion method. Isolates were divided into 6 groups based on their host age.The results showed that virulence factors PapGII, PapGIII, Cnf1, Aer, Usp, Iha, OmpT, HlyA, and Sat, had highest frequencies in the host age group 0-3. Phylogenetic group B2 dominated in our isolates (59.6%) followed by group D (20.7%). In addition, 77.4% of strains isolated from 0 to 3 age group belonged to phylogenetic group B2. Antimicrobial susceptibility tests showed that E. coli strains isolated were significantly more resistant to antimicrobial agents as host age increased. Phylogenetic group B2 isolates were more susceptible to antimicrobial agents, compared to A, B1, and D isolates.RESULTSThe results showed that virulence factors PapGII, PapGIII, Cnf1, Aer, Usp, Iha, OmpT, HlyA, and Sat, had highest frequencies in the host age group 0-3. Phylogenetic group B2 dominated in our isolates (59.6%) followed by group D (20.7%). In addition, 77.4% of strains isolated from 0 to 3 age group belonged to phylogenetic group B2. Antimicrobial susceptibility tests showed that E. coli strains isolated were significantly more resistant to antimicrobial agents as host age increased. Phylogenetic group B2 isolates were more susceptible to antimicrobial agents, compared to A, B1, and D isolates.We found E. coli isolated from elders were more resistant to antimicrobial agents and had less virulence factors.CONCLUSIONWe found E. coli isolated from elders were more resistant to antimicrobial agents and had less virulence factors. Background: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial virulence factors and antimicrobial susceptibility. Methods: PCRs were carried out to detect K1 capsule antigen, 15 virulence factors, and phylogenetic groups in E. coli isolates. Antimicrobial susceptibility of selected agents was determined by the disk diffusion method. Isolates were divided into 6 groups based on their host age. Results: The results showed that virulence factors PapGII, PapGIII, Cnf1, Aer, Usp, Iha, OmpT, HlyA, and Sat, had highest frequencies in the host age group 0–3. Phylogenetic group B2 dominated in our isolates (59.6%) followed by group D (20.7%). In addition, 77.4% of strains isolated from 0 to 3 age group belonged to phylogenetic group B2. Antimicrobial susceptibility tests showed that E. coli strains isolated were significantly more resistant to antimicrobial agents as host age increased. Phylogenetic group B2 isolates were more susceptible to antimicrobial agents, compared to A, B1, and D isolates. Conclusion: We found E. coli isolated from elders were more resistant to antimicrobial agents and had less virulence factors. |
| Author | Teng, Ching-Hao Kao, Cheng-Yen Lin, Wei-Hung Wang, Ming-Cheng Liu, Po-Yao Wen, Li-Li Chen, Po-Shun |
| Author_xml | – sequence: 1 givenname: Wei-Hung surname: Lin fullname: Lin, Wei-Hung organization: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan – sequence: 2 givenname: Ming-Cheng surname: Wang fullname: Wang, Ming-Cheng organization: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan – sequence: 3 givenname: Po-Yao surname: Liu fullname: Liu, Po-Yao organization: Institute of Microbiology and Immunology, School of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan – sequence: 4 givenname: Po-Shun surname: Chen fullname: Chen, Po-Shun organization: Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089-0482, United States – sequence: 5 givenname: Li-Li surname: Wen fullname: Wen, Li-Li organization: Department of Clinical Laboratory, En Chu Kong Hospital, New Taipei City, Taiwan – sequence: 6 givenname: Ching-Hao orcidid: 0000-0002-4615-094X surname: Teng fullname: Teng, Ching-Hao organization: Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan – sequence: 7 givenname: Cheng-Yen orcidid: 0000-0001-8782-3912 surname: Kao fullname: Kao, Cheng-Yen email: kaocy@ym.edu.tw organization: Institute of Microbiology and Immunology, School of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33972179$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkc1u1TAQhSNURH_gBVggL9nkYjs_Tio2qCq0UiU2sLbG9qSd4JtcbKfSfYK-Ng63dNFFWVi2Rucca853WhxN84RF8V7wjeCi_TRuxi3RRnIpNrzecC5eFSei75uyF1V1lN9tV5dCdPK4OI1x5LyuZNO-KY6rqldSqP6keLiM9g4D2TsCZmdPbAk0QdizFMAmRtOANtE8xXN2NcfE4BbLgB4SOuZoGDDgZDFmITPZkKPAs3sKi1_nbMizOUQGk8sn0ZZsmM2qiUu0uEtkyFPavy1eD-Ajvnu8z4qfXy9_XFyVN9-_XV98uSltI1Qqoa8GbrvWtAhGycYCl2hrZVQnjJHglKmgUh3UgzSD7GvVI_ZtJ3mNve1cdVZcH3LdDKPeBdrmXfUMpP8O5nCrISSyHrUElMqKRrqe1xYlDNYBOiW6SrUOTM76eMjahfn3gjHpLeWdvIcJ5yVq2eS2G6mqNks_PEoXs0X39PE_EFkgD4JcT4wBhyeJ4HqlrUe90tYrbc1rnWlnU_fMZCnBSivDI_-y9fPBirnse8Kgo6WVmKOQgec26GX7-TO79TSRBf8L9_8z_wHal9x8 |
| CitedBy_id | crossref_primary_10_1080_07391102_2023_2297007 crossref_primary_10_3390_microorganisms10020302 crossref_primary_10_47485_2693_2326_1027 crossref_primary_10_1007_s11033_024_09485_7 crossref_primary_10_3390_pathogens10091156 crossref_primary_10_1016_j_jmii_2024_12_007 crossref_primary_10_3390_pathogens13121068 crossref_primary_10_1007_s11033_023_09031_x crossref_primary_10_1186_s12985_024_02306_0 crossref_primary_10_2147_IDR_S458925 crossref_primary_10_52547_pbp_4_1_12 crossref_primary_10_1186_s12866_023_02820_1 crossref_primary_10_1093_heapol_czad054 crossref_primary_10_1016_j_ijregi_2024_100469 crossref_primary_10_1016_j_meegid_2023_105493 crossref_primary_10_1186_s12866_024_03290_9 crossref_primary_10_46234_ccdcw2023_110 crossref_primary_10_1016_j_micpath_2024_107000 crossref_primary_10_1016_j_jgar_2022_06_004 |
| Cites_doi | 10.1016/j.jmii.2011.12.024 10.1086/320198 10.1016/j.idc.2013.10.006 10.1128/JCM.02086-12 10.1177/1756287219832172 10.1016/j.jmii.2020.09.001 10.1093/ofid/ofv083 10.1128/microbiolspec.UTI-0002-2012 10.1111/lam.12517 10.1053/ajkd.2002.32992 10.1007/s10096-018-3302-y 10.1016/j.ijantimicag.2005.08.003 10.1016/j.jmii.2017.06.003 10.1128/CMR.00101-19 10.1086/427996 10.1086/669865 10.1086/343828 10.1186/s12866-020-01933-1 10.1128/AEM.66.10.4555-4558.2000 10.1007/s10096-014-2171-2 |
| ContentType | Journal Article |
| Copyright | 2021 Copyright © 2021. Published by Elsevier B.V. |
| Copyright_xml | – notice: 2021 – notice: Copyright © 2021. Published by Elsevier B.V. |
| DBID | 6I. AAFTH AAYXX CITATION NPM 7X8 DOA |
| DOI | 10.1016/j.jmii.2021.04.001 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef PubMed MEDLINE - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1995-9133 |
| EndPage | 256 |
| ExternalDocumentID | oai_doaj_org_article_2ae27c152d904ce2afcdaed718376dab 33972179 10_1016_j_jmii_2021_04_001 S1684118221000918 |
| Genre | Journal Article |
| GroupedDBID | --- --K .1- .FO .~1 0R~ 1B1 1P~ 1~. 1~5 2WC 4.4 457 4G. 53G 5GY 5VS 7-5 71M 8P~ AAEDW AAIKJ AALRI AAQFI AARKO AAXUO AAYWO ABBQC ABFRF ABMAC ABWVN ABXDB ACGFS ACRPL ACVFH ADBBV ADCNI ADMUD ADNMO ADVLN AEFWE AEKER AENEX AEUPX AEVXI AEXQZ AFJKZ AFPUW AFRHN AFTJW AGEKW AGHFR AGYEJ AIGII AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP BAWUL BCNDV DIK DU5 E3Z EBS EJD EP3 F5P FDB FEDTE FIRID FNPLU GBLVA GROUPED_DOAJ HVGLF HZ~ J1W LUGTX M41 MO0 N9A O-L O9- OD- OK1 OO. P-8 P-9 PC. Q38 ROL SDF SEL SES SSZ UNMZH WH7 Z5R 0SF 6I. AACTN AAFTH LCYCR NCXOZ RIG AAYXX CITATION NPM 7X8 |
| ID | FETCH-LOGICAL-c517t-a93f0c86b6eab725ca02ec47b781bb2ad7b3a378a4f2bf29479ee968204e9c8d3 |
| IEDL.DBID | DOA |
| ISSN | 1684-1182 1995-9133 |
| IngestDate | Wed Aug 27 01:26:42 EDT 2025 Thu Jul 10 19:11:19 EDT 2025 Mon Jul 21 06:00:42 EDT 2025 Thu Apr 24 23:08:39 EDT 2025 Tue Jul 01 04:09:37 EDT 2025 Fri Feb 23 02:41:22 EST 2024 Tue Aug 26 16:34:01 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Antimicrobial susceptibility Urinary tract infection Age-related differences Virulence factors Phylogenetic groups |
| Language | English |
| License | This is an open access article under the CC BY license. Copyright © 2021. Published by Elsevier B.V. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c517t-a93f0c86b6eab725ca02ec47b781bb2ad7b3a378a4f2bf29479ee968204e9c8d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8782-3912 0000-0002-4615-094X |
| OpenAccessLink | https://doaj.org/article/2ae27c152d904ce2afcdaed718376dab |
| PMID | 33972179 |
| PQID | 2525652736 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_2ae27c152d904ce2afcdaed718376dab proquest_miscellaneous_2525652736 pubmed_primary_33972179 crossref_primary_10_1016_j_jmii_2021_04_001 crossref_citationtrail_10_1016_j_jmii_2021_04_001 elsevier_sciencedirect_doi_10_1016_j_jmii_2021_04_001 elsevier_clinicalkey_doi_10_1016_j_jmii_2021_04_001 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | April 2022 2022-04-00 2022-Apr 20220401 2022-04-01 |
| PublicationDateYYYYMMDD | 2022-04-01 |
| PublicationDate_xml | – month: 04 year: 2022 text: April 2022 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Journal of microbiology, immunology and infection |
| PublicationTitleAlternate | J Microbiol Immunol Infect |
| PublicationYear | 2022 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Yazdanpour, Tadjrobehkar, Shahkhah (bib18) 2000; 20 Tseng, Lin, Wu, Wang, Teng, Wu (bib5) 2022; 55 Johnson, Porter, Johnston, Kuskowski, Spurbeck, Mobley (bib11) 2015; 2 Zhanel, Hisanaga, Laing, DeCorby, Nichol, Palatnik (bib20) 2005; 26 Stapleton (bib3) 2014; 28 Clermont, Bonacorsi, Bingen (bib16) 2000; 66 Nowrouzian, Wold, Adlerberth (bib19) 2005; 191 (bib17) 2020 Reitzer, Zimmern (bib8) 2019; 33 Kao, Lin, Tseng, Wu, Wang, Wu (bib13) 2014; 33 Johnson, O'Bryan, Delavari, Kuskowski, Stapleton, Carlino (bib10) 2001; 183 Tseng, Wang, Lin, Liao, Chen, Teng (bib6) 2018; 51 Lin, Tseng, Wu, Chang, Kuo, Chao (bib15) 2018; 37 Geerlings (bib2) 2016; 4 Wang, Tseng, Chen, Wu, Huang (bib7) 2002; 35 Banerjee, Johnston, Lohse, Porter, Clabots, Johnson (bib21) 2013; 34 Medina, Castillo-Pino (bib1) 2019; 11 Luo, Ma, Zhao, Wang, Guo, Ye (bib12) 2012; 50 Tseng, Wu, Liu, Sung, Huang (bib14) 2002; 39 Wang, Tseng, Wu, Lin, Teng, Yan (bib9) 2013; 46 Lee, Subhadra, Son, Kim, Park, Kim (bib4) 2016; 62 Lee (10.1016/j.jmii.2021.04.001_bib4) 2016; 62 Tseng (10.1016/j.jmii.2021.04.001_bib6) 2018; 51 Kao (10.1016/j.jmii.2021.04.001_bib13) 2014; 33 Yazdanpour (10.1016/j.jmii.2021.04.001_bib18) 2000; 20 Reitzer (10.1016/j.jmii.2021.04.001_bib8) 2019; 33 Nowrouzian (10.1016/j.jmii.2021.04.001_bib19) 2005; 191 Wang (10.1016/j.jmii.2021.04.001_bib7) 2002; 35 Lin (10.1016/j.jmii.2021.04.001_bib15) 2018; 37 Medina (10.1016/j.jmii.2021.04.001_bib1) 2019; 11 Luo (10.1016/j.jmii.2021.04.001_bib12) 2012; 50 Johnson (10.1016/j.jmii.2021.04.001_bib10) 2001; 183 Tseng (10.1016/j.jmii.2021.04.001_bib14) 2002; 39 Wang (10.1016/j.jmii.2021.04.001_bib9) 2013; 46 (10.1016/j.jmii.2021.04.001_bib17) 2020 Johnson (10.1016/j.jmii.2021.04.001_bib11) 2015; 2 Zhanel (10.1016/j.jmii.2021.04.001_bib20) 2005; 26 Stapleton (10.1016/j.jmii.2021.04.001_bib3) 2014; 28 Geerlings (10.1016/j.jmii.2021.04.001_bib2) 2016; 4 Tseng (10.1016/j.jmii.2021.04.001_bib5) 2022; 55 Clermont (10.1016/j.jmii.2021.04.001_bib16) 2000; 66 Banerjee (10.1016/j.jmii.2021.04.001_bib21) 2013; 34 |
| References_xml | – volume: 34 start-page: 361 year: 2013 end-page: 369 ident: bib21 article-title: Escherichia coli sequence type 131 is a dominant, antimicrobial-resistant clonal group associated with healthcare and elderly hosts publication-title: Infect Control Hosp Epidemiol – volume: 37 start-page: 1699 year: 2018 end-page: 1707 ident: bib15 article-title: Clinical and microbiological characteristics of peritoneal dialysis-related peritonitis caused by Escherichia coli in southern Taiwan publication-title: Eur J Clin Microbiol Infect Dis – volume: 20 start-page: 241 year: 2000 ident: bib18 article-title: Significant association between genes encoding virulence factors with antibiotic resistance and phylogenetic groups in community acquired uropathogenic Escherichia coli isolates publication-title: BMC Microbiol – volume: 28 start-page: 149 year: 2014 end-page: 159 ident: bib3 article-title: Urinary tract infection pathogenesis: host factors publication-title: Infect Dis Clin North Am – volume: 2 start-page: ofv083 year: 2015 ident: bib11 article-title: Host characteristics and bacterial traits predict experimental virulence for Escherichia coli bloodstream isolates from patients with urosepsis publication-title: Open Forum Infect Dis – volume: 66 start-page: 4555 year: 2000 end-page: 4558 ident: bib16 article-title: Rapid and simple determination of the Escherichia coli phylogenetic group publication-title: Appl Environ Microbiol – volume: 35 start-page: 1161 year: 2002 end-page: 1166 ident: bib7 article-title: The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection publication-title: Clin Infect Dis – volume: 33 start-page: 2157 year: 2014 end-page: 2162 ident: bib13 article-title: The complex interplay among bacterial motility and virulence factors in different Escherichia coli infections publication-title: Eur J Clin Microbiol Infect Dis – volume: 191 start-page: 1078 year: 2005 end-page: 1083 ident: bib19 article-title: Escherichia coli strains belonging to phylogenetic group B2 have superior capacity to persist in the intestinal microflora of infants publication-title: J Infect Dis – volume: 4 year: 2016 ident: bib2 article-title: Clinical presentations and epidemiology of urinary tract infections publication-title: Microbiol Spectr – volume: 62 start-page: 84 year: 2016 end-page: 90 ident: bib4 article-title: Phylogenetic group distributions, virulence factors and antimicrobial resistance properties of uropathogenic Escherichia coli strains isolated from patients with urinary tract infections in South Korea publication-title: Lett Appl Microbiol – volume: 33 start-page: e00101 year: 2019 end-page: e00119 ident: bib8 article-title: Rapid growth and metabolism of uropathogenic Escherichia coli in relation to urine composition publication-title: Clin Microbiol Rev – volume: 55 start-page: 44 year: 2022 end-page: 50 ident: bib5 article-title: FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection publication-title: J Microbiol Immunol Infect – year: 2020 ident: bib17 article-title: Performance Standards for antimicrobial susceptibility testing – volume: 46 start-page: 24 year: 2013 end-page: 29 ident: bib9 article-title: Bacterial characteristics and glycemic control in diabetic patients with Escherichia coli urinary tract infection publication-title: J Microbiol Immunol Infect – volume: 39 start-page: 744 year: 2002 end-page: 752 ident: bib14 article-title: Roles of host and bacterial virulence factors in the development of upper urinary tract infection caused by Escherichia coli publication-title: Am J Kidney Dis – volume: 11 year: 2019 ident: bib1 article-title: An introduction to the epidemiology and burden of urinary tract infections publication-title: Ther Adv Urol – volume: 50 start-page: 4002 year: 2012 end-page: 4007 ident: bib12 article-title: Similarity and divergence of phylogenies, antimicrobial susceptibilities, and virulence factor profiles of Escherichia coli isolates causing recurrent urinary tract infections that persist or result from reinfection publication-title: J Clin Microbiol – volume: 26 start-page: 380 year: 2005 end-page: 388 ident: bib20 article-title: Antibiotic resistance in outpatient urinary isolates: final results from the north American urinary tract infection collaborative alliance (NAUTICA) publication-title: Int J Antimicrob Agents – volume: 51 start-page: 492 year: 2018 end-page: 499 ident: bib6 article-title: Role of class II P fimbriae and cytokine response in the pathogenesis of Escherichia coli kidney infection in diabetic mice publication-title: J Microbiol Immunol Infect – volume: 183 start-page: 1508 year: 2001 end-page: 1517 ident: bib10 article-title: Clonal relationships and extended virulence genotypes among Escherichia coli isolates from women with a first or recurrent episode of cystitis publication-title: J Infect Dis – volume: 46 start-page: 24 year: 2013 ident: 10.1016/j.jmii.2021.04.001_bib9 article-title: Bacterial characteristics and glycemic control in diabetic patients with Escherichia coli urinary tract infection publication-title: J Microbiol Immunol Infect doi: 10.1016/j.jmii.2011.12.024 – volume: 183 start-page: 1508 year: 2001 ident: 10.1016/j.jmii.2021.04.001_bib10 article-title: Clonal relationships and extended virulence genotypes among Escherichia coli isolates from women with a first or recurrent episode of cystitis publication-title: J Infect Dis doi: 10.1086/320198 – volume: 28 start-page: 149 year: 2014 ident: 10.1016/j.jmii.2021.04.001_bib3 article-title: Urinary tract infection pathogenesis: host factors publication-title: Infect Dis Clin North Am doi: 10.1016/j.idc.2013.10.006 – year: 2020 ident: 10.1016/j.jmii.2021.04.001_bib17 – volume: 50 start-page: 4002 year: 2012 ident: 10.1016/j.jmii.2021.04.001_bib12 article-title: Similarity and divergence of phylogenies, antimicrobial susceptibilities, and virulence factor profiles of Escherichia coli isolates causing recurrent urinary tract infections that persist or result from reinfection publication-title: J Clin Microbiol doi: 10.1128/JCM.02086-12 – volume: 11 year: 2019 ident: 10.1016/j.jmii.2021.04.001_bib1 article-title: An introduction to the epidemiology and burden of urinary tract infections publication-title: Ther Adv Urol doi: 10.1177/1756287219832172 – volume: 55 start-page: 44 year: 2022 ident: 10.1016/j.jmii.2021.04.001_bib5 article-title: Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection publication-title: J Microbiol Immunol Infect doi: 10.1016/j.jmii.2020.09.001 – volume: 2 start-page: ofv083 year: 2015 ident: 10.1016/j.jmii.2021.04.001_bib11 article-title: Host characteristics and bacterial traits predict experimental virulence for Escherichia coli bloodstream isolates from patients with urosepsis publication-title: Open Forum Infect Dis doi: 10.1093/ofid/ofv083 – volume: 4 year: 2016 ident: 10.1016/j.jmii.2021.04.001_bib2 article-title: Clinical presentations and epidemiology of urinary tract infections publication-title: Microbiol Spectr doi: 10.1128/microbiolspec.UTI-0002-2012 – volume: 62 start-page: 84 year: 2016 ident: 10.1016/j.jmii.2021.04.001_bib4 article-title: Phylogenetic group distributions, virulence factors and antimicrobial resistance properties of uropathogenic Escherichia coli strains isolated from patients with urinary tract infections in South Korea publication-title: Lett Appl Microbiol doi: 10.1111/lam.12517 – volume: 39 start-page: 744 year: 2002 ident: 10.1016/j.jmii.2021.04.001_bib14 article-title: Roles of host and bacterial virulence factors in the development of upper urinary tract infection caused by Escherichia coli publication-title: Am J Kidney Dis doi: 10.1053/ajkd.2002.32992 – volume: 37 start-page: 1699 year: 2018 ident: 10.1016/j.jmii.2021.04.001_bib15 article-title: Clinical and microbiological characteristics of peritoneal dialysis-related peritonitis caused by Escherichia coli in southern Taiwan publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-018-3302-y – volume: 26 start-page: 380 year: 2005 ident: 10.1016/j.jmii.2021.04.001_bib20 article-title: Antibiotic resistance in outpatient urinary isolates: final results from the north American urinary tract infection collaborative alliance (NAUTICA) publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2005.08.003 – volume: 51 start-page: 492 year: 2018 ident: 10.1016/j.jmii.2021.04.001_bib6 article-title: Role of class II P fimbriae and cytokine response in the pathogenesis of Escherichia coli kidney infection in diabetic mice publication-title: J Microbiol Immunol Infect doi: 10.1016/j.jmii.2017.06.003 – volume: 33 start-page: e00101 issue: 1 year: 2019 ident: 10.1016/j.jmii.2021.04.001_bib8 article-title: Rapid growth and metabolism of uropathogenic Escherichia coli in relation to urine composition publication-title: Clin Microbiol Rev doi: 10.1128/CMR.00101-19 – volume: 191 start-page: 1078 year: 2005 ident: 10.1016/j.jmii.2021.04.001_bib19 article-title: Escherichia coli strains belonging to phylogenetic group B2 have superior capacity to persist in the intestinal microflora of infants publication-title: J Infect Dis doi: 10.1086/427996 – volume: 34 start-page: 361 year: 2013 ident: 10.1016/j.jmii.2021.04.001_bib21 article-title: Escherichia coli sequence type 131 is a dominant, antimicrobial-resistant clonal group associated with healthcare and elderly hosts publication-title: Infect Control Hosp Epidemiol doi: 10.1086/669865 – volume: 35 start-page: 1161 year: 2002 ident: 10.1016/j.jmii.2021.04.001_bib7 article-title: The role of bacterial virulence and host factors in patients with Escherichia coli bacteremia who have acute cholangitis or upper urinary tract infection publication-title: Clin Infect Dis doi: 10.1086/343828 – volume: 20 start-page: 241 year: 2000 ident: 10.1016/j.jmii.2021.04.001_bib18 article-title: Significant association between genes encoding virulence factors with antibiotic resistance and phylogenetic groups in community acquired uropathogenic Escherichia coli isolates publication-title: BMC Microbiol doi: 10.1186/s12866-020-01933-1 – volume: 66 start-page: 4555 year: 2000 ident: 10.1016/j.jmii.2021.04.001_bib16 article-title: Rapid and simple determination of the Escherichia coli phylogenetic group publication-title: Appl Environ Microbiol doi: 10.1128/AEM.66.10.4555-4558.2000 – volume: 33 start-page: 2157 year: 2014 ident: 10.1016/j.jmii.2021.04.001_bib13 article-title: The complex interplay among bacterial motility and virulence factors in different Escherichia coli infections publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-014-2171-2 |
| SSID | ssj0043256 |
| Score | 2.4157128 |
| Snippet | Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial... Background: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections.... |
| SourceID | doaj proquest pubmed crossref elsevier |
| SourceType | Open Website Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 249 |
| SubjectTerms | Age-related differences Antimicrobial susceptibility Phylogenetic groups Urinary tract infection Virulence factors |
| SummonAdditionalLinks | – databaseName: ScienceDirect Freedom Collection 2013 dbid: .~1 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhUOilNH1u-kCF3oq7a1myrN7akLAU2ksbyE3o5aLQeMPaW9hLrv3bnZFlQw5NoQdfzMjyesajz9pvviHkbc0g7SnfFB6ip-CtbYvGhqaQAcB8sEaVFvc7vnyt1-f884W4OCAnUy0M0ipz7h9zesrW-cwyP83ldYzLb2XdcITHDLeoVYkFv5xLjPL3NzPNg1csdXBF4wKtc-HMyPG6vIoRvhFZmeROc2OYaXFKGv631qi_YdC0Fp09JA8yiKQfx_s8Igehe0TujW0l94_J79MeXRGRxkzB0ZHilrrZ7umANVF0ImB1_Qe63vQDhZxSpKKW4OnUMQXyBxhSO6o5w2y_4naXKpRo7tFDTefhGOJVTGpOYNPv-kSTSYzb_RNyfnb6_WRd5IYLhROlHAqjqnblmtrWwVjJhDMrFhyXVgK4tcx4aStTycbwltmWKS5VCKoGEMGDco2vnpLDbtOF54Qy34rKeeNLZ7ljzAC0EI0RLBiAjK1YkHJ60tplNXJsivFTT7SzS43e0egdveLIvVuQd_OY61GL407rT-jA2RJ1tNOJzfaHzoGkmQlMOsAwXq049kZr4Z6DhwUbEq83dkGqyf16KlWF5AoXindOLeZRt4L5n-PeTBGm4S3Hv25MFza7XjMBYYxaefWCPBtDb_5hVYUKTFId_-esL8h9hjUdiY70khwO2114BUhrsK_Tq_QH8-so1Q priority: 102 providerName: Elsevier |
| Title | Escherichia coli urinary tract infections: Host age-related differences in bacterial virulence factors and antimicrobial susceptibility |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S1684118221000918 https://dx.doi.org/10.1016/j.jmii.2021.04.001 https://www.ncbi.nlm.nih.gov/pubmed/33972179 https://www.proquest.com/docview/2525652736 https://doaj.org/article/2ae27c152d904ce2afcdaed718376dab |
| Volume | 55 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagEhIXVN5baGUkbsiwcew45kZRqxUSnKjUm-VXpFQ0izZZpL1w5W8zY8crONBeOOQS2XnNeOZL8s03hLxuOIQ9HVoWwHuY6FzHWhdbpiKA-eisrhx-7_j8pVldiE-X8vKPVl_ICcvywPnBveM2cuUhywS9FNi9qvPBxgAhFZZGsA6jL-S88jKVY7CoeerbWjWtYAih53KZzOy6uu57eDPkVRI5ndvBlJSUlPv_ykz_Qp4pA50fkgczdKQf8iU_JHfi8Ijcy80kd4_Jr7MRDdAjeZmCeXuKH9LtZkcnrISihXY1jO_paj1OFCIJS6UsMdDSJwWiBgykLms4w9l-9Jttqkuic2ceaocA29Rf90nDCcaM2zGRYxLPdveEXJyfff24YnObBeZlpSZmdd0tfdu4JlqnuPR2yaMXyimAtI7boFxta9Va0XHXcS2UjlE3AB1E1L4N9VNyMKyH-JxQHjpZg31C5Z3wnFsAFLK1kkcLQLGTC1KVJ238rEGOrTC-mUI2uzJoHYPWMUuBjLsFebOf8z0rcNw4-hQNuB-J6tlpB_iUmX3K3OZTC1IX85tSoAohFQ7U33hquZ81w5cMS26d96p4mIG1jT9s7BDX29FwCW6MCnnNgjzLrre_sbpG3SWlj_7HDb8g9zmWdSRG0ktyMG228RjA1uROyN23P6uTtLp-A8BMKwc |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKEYIL4s3yNBI3FHbjOHHMDapWC7S90Eq9WX4FuaLZapNF2gtX_jYzjhOpB4rEYS_ReJ3NjMdfvN98Q8jbikHak67OHERPxhvTZLXxdSY8gHlvtMwNnnccHVfLU_7lrDzbIXtjLQzSKlPuH3J6zNbpyjw9zfllCPNveVVzhMcMj6hlXt8gNzksX1yd739NPA9esNjCFa0zNE-VMwPJ6_wiBHhJZHnUO02dYcbdKYr4X9mk_gZC42Z0cI_cTSiSfhxu9D7Z8e0DcmvoK7l9SH7vd-iLgDxmCp4OFM_U9XpLeyyKoiMDq-0-0OWq6ykklSxWtXhHx5YpkEDAkJpBzhlm-xnWm1iiRFOTHqpbB58-XIQo5wQ23aaLPJlIud0-IqcH-yd7yyx1XMhsmYs-07JoFrauTOW1Eay0esG85cIIQLeGaSdMoQtRa94w0zDJhfReVoAiuJe2dsVjstuuWv-UUOaasrBOu9wabhnTgC3KWpfMa8CMTTkj-fiklU1y5NgV44caeWfnCr2j0DtqwZF8NyPvpjGXgxjHtdaf0IGTJQppxwur9XeVIkkx7ZmwAGKcXHBsjtbAPXsHOzZkXqfNjBSj-9VYqwrZFb4oXDt1OY26Es3_HPdmjDAFyxz_u9GtX206xUoIYxTLq2bkyRB60w8rCpRgEvLZf876mtxenhwdqsPPx1-fkzsMCzwiN-kF2e3XG_8SYFdvXsVl9QfIEivw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Escherichia+coli+urinary+tract+infections%3A+Host+age-related+differences+in+bacterial+virulence+factors+and+antimicrobial+susceptibility&rft.jtitle=Journal+of+microbiology%2C+immunology+and+infection&rft.au=Lin%2C+Wei-Hung&rft.au=Wang%2C+Ming-Cheng&rft.au=Liu%2C+Po-Yao&rft.au=Chen%2C+Po-Shun&rft.date=2022-04-01&rft.issn=1995-9133&rft.eissn=1995-9133&rft.volume=55&rft.issue=2&rft.spage=249&rft_id=info:doi/10.1016%2Fj.jmii.2021.04.001&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1684-1182&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1684-1182&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1684-1182&client=summon |