Lymphatic vessels in human adipose tissue

Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneo...

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Published inCell and tissue research Vol. 379; no. 3; pp. 511 - 520
Main Authors Redondo, Patricia de Albuquerque Garcia, Gubert, Fernanda, Zaverucha-do-Valle, Camila, Dutra, Tatiana Pereira Pena, Ayres-Silva, Jackline de Paula, Fernandes, Natasha, de Souza, Antonio Augusto Peixoto, Loizidou, Marilena, Takiya, Christina Maeda, Rossi, Maria Isabel Doria, Borojevic, Radovan
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2020
Springer
Springer Nature B.V
Subjects
Adipose tissue
Adipose tissues
Biomedical and Life Sciences
Biomedicine
Capillaries
Human Genetics
Lymphatic system
Molecular Medicine
Parenchyma
Proteomics
Regular Article
Type 2 diabetes
Visceral
Adipose
Lymphatics
Subcutaneous
Vessels
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Summary:Despite being considered present in most vascularised tissues, lymphatic vessels have not been properly shown in human adipose tissue (AT). Our goal in this study is to investigate an unanswered question in AT biology, regarding lymphatic network presence in tissue parenchyma. Using human subcutaneous (S-) and visceral (V-) AT samples with whole mount staining for lymphatic specific markers and three-dimensional imaging, we showed lymphatic capillaries and larger lymphatic vessels in the human VAT. Conversely, in the human SAT, microcirculatory lymphatic vascular structures were rarely detected and no initial lymphatics were found.
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ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-019-03108-5