Protein engineering strategies for microbial production of isoprenoids

• Published in: Metabolic engineering communications Vol. 11; p. e00129
• Main Authors: Daletos, Georgios, Stephanopoulos, Gregory
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2020; Elsevier
• Subjects: Activity; Enzyme engineering; Isoprenoids; Microbial hosts; Promiscuity; Selectivity; Special issue on The Natural Product Issue edited by Greg Stephanopoulos, Anthony Sinskey and Kang Zhou; Microbial hosts; Activity; Selectivity; Enzyme engineering; Promiscuity; Isoprenoids

Isoprenoids comprise one of the most chemically diverse family of natural products with high commercial interest. The structural diversity of isoprenoids is mainly due to the modular activity of three distinct classes of enzymes, including prenyl diphosphate synthases, terpene synthases, and cytochr...