The PD-1/PD-L pathway in rheumatic diseases

• Published in: Journal of the Formosan Medical Association Vol. 120; no. 1; pp. 48 - 59
• Main Authors: Zhang, Shuo, Wang, Li, Li, Mengtao, Zhang, Fengchun, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier B.V 01.01.2021; Elsevier
• Subjects: Animals; Autoimmunity; B7-H1 Antigen; Genetic susceptibility; Humans; Pathogenesis; Pathway; Programmed Cell Death 1 Receptor - genetics; Programmed death-1; Rheumatic diseases; Rheumatic Diseases - genetics; Genetic susceptibility; Pathogenesis; Pathway; Rheumatic diseases; Programmed death-1

Autoimmune diseases are diseases in which the body produces an abnormal immune response to self-antigens and damages its own tissues. Programmed death-1 (PD-1) and its ligands (PD-Ls) have been discovered to be important negative regulators of the immune system, playing crucial roles in autoimmunity...