Relationships between Beta-Amyloid and Functional Connectivity in Different Components of the Default Mode Network in Aging

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 21; no. 10; pp. 2399 - 2407
• Main Authors: Mormino, Elizabeth C., Smiljic, Andre, Hayenga, Amynta O., H. Onami, Susan, Greicius, Michael D., Rabinovici, Gil D., Janabi, Mustafa, Baker, Suzanne L., V. Yen, Irene, Madison, Cindee M., Miller, Bruce L., Jagust, William J.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.10.2011
• Subjects: Adult; Aged; Aged, 80 and over; Aging - pathology; Aging - physiology; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - biosynthesis; Amyloid beta-Peptides - physiology; Brain Mapping - methods; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Cortex - physiology; Cohort Studies; Female; Humans; Male; Memory, Episodic; Nerve Net - diagnostic imaging; Nerve Net - metabolism; Nerve Net - physiopathology; Positron-Emission Tomography - methods; Young Adult; beta-amyloid; aging; resting state fMRI; PIB-PET

Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition as detected with Pittsburgh compound-B positron emission tomography (PIB-PET) imaging shows substantial s...