Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology - Hirata, Tetsuya; Kobayashi, Atsushi; Furuse, Tamio; Yamada, Ikuko; Tamura, Masaru; Tomita, Hiroyuki; Tokoro, Yuko; Ninomiya, Akinori; Fujihara, Yoshitaka; Ikawa, Masahito; Maeda, Yusuke; Murakami, Yoshiko; et al. (The Journal of biological chemistry, 2022)
Keywords: Acetylgalactosamine - chemistry; Acetylgalactosamine - metabolism; Animals; bone formation; Brain - metabolism; brain function; Creutzfeldt–Jakob disease; glycosylation; Glycosylphosphatidylinositols - chemistry; Glycosylphosphatidylinositols - metabolism; glycosyltransferase; GPI; Mice; Osteogenesis; prion; Prion Diseases - metabolism; Prions - metabolism; Structure-Activity Relationship; GPI; PrPSc; ALP; IHC; HRP; brain function; 2ME; WB; RBC; DW; prion; Creutzfeldt–Jakob disease; ISH; TBS; GSS; MS; IGD; glycosylation; ER; GPI-AP; ES; PrPC; glycosyltransferase; bone formation; PK; DRM