Solubility and Physical Stability Enhancement of Loratadine by Preparation of Co-Amorphous Solid Dispersion with Chlorpheniramine and Polyvinylpyrrolidone

• Published in: Pharmaceutics Vol. 15; no. 11; p. 2558
• Main Authors: Suknuntha, Krit, Khumpirapang, Nattakanwadee, Tantishaiyakul, Vimon, Okonogi, Siriporn
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.10.2023
• Subjects: Aluminum; amorphous; Bioavailability; Calorimetry; Chlorpheniramine; Diffraction; Drug dosages; Ethanol; Fourier transforms; Histamine; Infrared spectroscopy; Loratadine; Oral administration; Polymers; polyvinylpyrrolidone; Povidone; solid dispersion; solubility enhancement; Spectrum analysis; X-rays; Thailand; United States > US; amorphous; film casting; quench cooling; solid dispersion; polyvinylpyrrolidone; loratadine; solubility enhancement; chlorpheniramine

Loratadine (LRD), a non-sedating and slow-acting antihistamine, is often given in combination with short-onset chlorpheniramine maleate (CPM) to increase efficacy. However, LRD has poor water solubility resulting in low bioavailability. The aim of this study was to improve LRD solubility by preparin...