HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain

• Published in: Journal of headache and pain Vol. 23; no. 1; pp. 102 - 20
• Main Authors: Du, Yu, Xu, Ceng-Lin, Yu, Jie, Liu, Keyue, Lin, Shi-Da, Hu, Ting-Ting, Qu, Feng-Hui, Guo, Fang, Lou, Guo-Dong, Nishibori, Masahiro, Hu, Wei-Wei, Chen, Zhong, Zhang, Shi-Hong
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.12.2022; Springer Nature B.V; BMC
• Subjects: Anxiety; Astrocytes; Aversion; Comorbid mood disorders; Comorbidity; Cytokines; Cytoplasm; Excitability; Genetics; High mobility group proteins; HMGB1; HMGB1 protein; Immunohistochemistry; Inflammation; Information processing; Internal Medicine; Medicine; Medicine & Public Health; Microglia; Monoclonal antibodies; mPFC; Neuralgia; Neuroinflammation; Neurological disorders; Neurology; Neuropathic pain; Optics; Pain; Pain Medicine; Pain perception; Place preference conditioning; Prefrontal cortex; Pyramidal cells; Sciatic nerve; Western blotting; Neuroinflammation; mPFC; Comorbid mood disorders; Anxiety; HMGB1; Neuropathic pain

Background Whether neuroinflammation causes comorbid mood disorders in neuropathic pain remains elusive. Here we investigated the role of high mobility group box 1 protein (HMGB1), a proinflammatory cytokine, in the medial prefrontal cortex (mPFC) in anxiety comorbidity of neuropathic pain. Methods...