Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes cau...

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Published inNature communications Vol. 11; no. 1; p. 5433
Main Authors Reis, Mouzarllem B., Rodrigues, Fernanda L., Lautherbach, Natalia, Kanashiro, Alexandre, Sorgi, Carlos A., Meirelles, Alyne F. G., Silva, Carlos A. A., Zoccal, Karina F., Souza, Camila O. S., Ramos, Simone G., Matsuno, Alessandra K., Rocha, Lenaldo B., Salgado, Helio C., Navegantes, Luiz C. C., Kettelhut, Ísis C., Cupo, Palmira, Gardinassi, Luiz G., Faccioli, Lúcia H.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.10.2020
Nature Publishing Group
Nature Portfolio
Subjects
13/21
13/31
38
38/77
49/1
631/250/256/2516
631/250/371
64/60
692/4019/592
Acetylcholine
Atropine
Congestive heart failure
Death
Dexamethasone
Edema
Heart failure
Humanities and Social Sciences
Inflammation
Interleukin 1
Interleukin 1 receptors
Morbidity
Mortality
multidisciplinary
Parasympathetic nervous system
Prostaglandin E2
Receptors
Risk reduction
Science
Science (multidisciplinary)
Signaling
Vagotomy
Venom
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Abstract Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are mediated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E 2, and acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure and mortality of envenomed mice. Therefore, we propose the use of dexamethasone administration very early after envenomation, even before antiserum, to inhibit the production of inflammatory mediators and acetylcholine release, and to reduce the risk of death. Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
AbstractList Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are mediated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E 2, and acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure and mortality of envenomed mice. Therefore, we propose the use of dexamethasone administration very early after envenomation, even before antiserum, to inhibit the production of inflammatory mediators and acetylcholine release, and to reduce the risk of death.
Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are mediated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E2, and acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure and mortality of envenomed mice. Therefore, we propose the use of dexamethasone administration very early after envenomation, even before antiserum, to inhibit the production of inflammatory mediators and acetylcholine release, and to reduce the risk of death.Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are mediated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E 2, and acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure and mortality of envenomed mice. Therefore, we propose the use of dexamethasone administration very early after envenomation, even before antiserum, to inhibit the production of inflammatory mediators and acetylcholine release, and to reduce the risk of death. Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality.
ArticleNumber 5433
Author Reis, Mouzarllem B.
Faccioli, Lúcia H.
Zoccal, Karina F.
Kettelhut, Ísis C.
Sorgi, Carlos A.
Cupo, Palmira
Matsuno, Alessandra K.
Gardinassi, Luiz G.
Rodrigues, Fernanda L.
Navegantes, Luiz C. C.
Lautherbach, Natalia
Souza, Camila O. S.
Kanashiro, Alexandre
Salgado, Helio C.
Meirelles, Alyne F. G.
Silva, Carlos A. A.
Ramos, Simone G.
Rocha, Lenaldo B.
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Snippet Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede...
Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by...
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SubjectTerms 13/21
13/31
38
38/77
49/1
631/250/256/2516
631/250/371
64/60
692/4019/592
Acetylcholine
Atropine
Congestive heart failure
Death
Dexamethasone
Edema
Heart failure
Humanities and Social Sciences
Inflammation
Interleukin 1
Interleukin 1 receptors
Morbidity
Mortality
multidisciplinary
Parasympathetic nervous system
Prostaglandin E2
Receptors
Risk reduction
Science
Science (multidisciplinary)
Signaling
Vagotomy
Venom
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Title Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation
URI https://link.springer.com/article/10.1038/s41467-020-19232-8
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https://pubmed.ncbi.nlm.nih.gov/PMC7595177
https://doaj.org/article/3824a55bb5ce42fc8ddfb1f913df0a2a
Volume 11
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