The gut microbiota and diabetic nephropathy: an observational study review and bidirectional Mendelian randomization study

• Published in: Current controlled trials in cardiovascular medicine Vol. 26; no. 1; pp. 101 - 25
• Main Authors: Han, Yi Zhen, Wang, Yang Zhi Yuan, Zhu, Xing Yu, Du, Bo Xuan, Wang, Yao Xian, Zhang, Xue Qin, Jia, Jia Meng, Liu, Wei Jing, Zheng, Hui Juan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.03.2025; BioMed Central; BMC
• Subjects: Analysis; Confounding (Statistics); Diabetes; Diabetic nephropathies; Diabetic Nephropathies - genetics; Diabetic Nephropathies - microbiology; Diabetic nephropathy; Ethics; Gastrointestinal Microbiome - genetics; Genetically modified organisms; Genome-Wide Association Study; Genomes; Genomics; Gut microbiota; Gut–kidney axis; Humans; Kidney diseases; Mapping; Mendelian randomization; Mendelian Randomization Analysis; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Observational studies; Observational Studies as Topic; Review; Sample size; Variables; Gut microbiota; Diabetic nephropathy; Mendelian randomization; Gut–kidney axis; Observational studies

Earlier studies have implicated a crucial link between diabetic nephropathy (DN) and the gut microbiota (GM) by considering the gut-kidney axis; however, the specific cause-and-effect connections between these processes remain unclear. To compare changes in the GM between DN patients and control sub...