Correlation between structural heart disease and cardiac SARS-CoV-2 manifestations

• Published in: Communications medicine Vol. 2; no. 1; p. 142
• Main Authors: Nägele, Felix, Graber, Michael, Hirsch, Jakob, Pölzl, Leo, Sahanic, Sabina, Fiegl, Manuel, Hau, Dominik, Engler, Clemens, Lechner, Sophia, Stalder, Anna Katharina, Mertz, Kirsten D., Haslbauer, Jasmin D., Tzankov, Alexandar, Grimm, Michael, Tancevski, Ivan, Holfeld, Johannes, Gollmann-Tepeköylü, Can
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.11.2022; Springer Nature B.V; Nature Portfolio
• Subjects: 14/63; 38/77; 59; 692/420/256; 692/699/75/74; Autopsies; Cardiomyocytes; Cardiovascular disease; Coronaviruses; Correlation analysis; COVID-19; Fatalities; Fibroblasts; Heart; Hospitalization; Hospitals; Infections; Medical prognosis; Medicine; Medicine & Public Health; Patients; Proteins; Severe acute respiratory syndrome coronavirus 2; Statistical analysis; Viral infections

Background: The prognosis of COVID-19 patients with cardiac involvement is unfavorable and it remains unknown which patients are at risk. The virus enters cells via its receptor angiotensin-converting enzyme 2 (ACE2). Myocardial ACE2 expression is increased in structural heart disease (SHD). We, the...