Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment

• Published in: Brain (London, England : 1878) Vol. 137; no. 5; pp. 1550 - 1561
• Main Authors: Mattsson, Niklas, Tosun, Duygu, Insel, Philip S., Simonson, Alix, Jack, Clifford R, Beckett, Laurel A., Donohue, Michael, Jagust, William, Schuff, Norbert, Weiner, Michael W.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2014
• Subjects: Adult and adolescent clinical studies; Aged; Aged, 80 and over; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Aniline Compounds; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Canada; Cerebrovascular Circulation - physiology; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - pathology; Databases, Factual - statistics & numerical data; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Ethylene Glycols; Female; Geriatrics; Humans; Male; Medical sciences; Mental Status Schedule; Middle Aged; Neurologi; Neurology; Organic mental disorders. Neuropsychology; Original; Positron-Emission Tomography; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Regional Blood Flow; Spin Labels; United States; Vascular diseases and vascular malformations of the nervous system; beta-amyloid; perfusion imaging; magnetic resonance imaging; Alzheimer’s disease; PET imaging; Radionuclide study; Nervous system diseases; Cognitive disorder; Alzheimer disease; Central nervous system; Nuclear magnetic resonance imaging; Cerebral disorder; Encephalon; Perfusion imaging; Central nervous system disease; Medical imagery; Degenerative disease; Amyloid; mild cognitive impairment; Positron emission tomography; Alzheimer's disease

Patients with Alzheimer’s disease show reduced cerebral blood flow, but it is unclear how this relates to β-amyloid pathology. By comparing patients with Alzheimer’s dementia, mild cognitive impairment, and controls, Mattsson et al. show that high β-amyloid load is associated with increased atrophy...