Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase

• Published in: Nature medicine Vol. 14; no. 7; pp. 723 - 730
• Main Authors: Faghihi, Mohammad Ali, Modarresi, Farzaneh, Khalil, Ahmad M, Wood, Douglas E, Sahagan, Barbara G, Morgan, Todd E, Finch, Caleb E, St. Laurent III, Georges, Kenny, Paul J, Wahlestedt, Claes
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.07.2008; Nature Publishing Group
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - enzymology; Alzheimer Disease - etiology; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid beta-protein; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - metabolism; Animals; Antisense RNA; Aspartic Acid Endopeptidases - genetics; Aspartic Acid Endopeptidases - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Line, Tumor; Development and progression; Feedback, Physiological; Gene expression; Gene Expression Regulation; Genetic aspects; Health aspects; Humans; Infectious Diseases; Male; Metabolic Diseases; Mice; Mice, Transgenic; Middle Aged; Models, Genetic; Molecular Medicine; Neuroblastoma - pathology; Neurosciences; Peptide Fragments - metabolism; Physiological aspects; Protein Processing, Post-Translational; RNA, Messenger - metabolism; RNA, Small Interfering - pharmacology; RNA, Untranslated - analysis; RNA, Untranslated - metabolism; Transcription, Genetic; Transfection; United States

BACE is an enzyme necessary for the generation of neurotoxic amyloid-β in Alzheimer's disease. Claes Wahlestedt and his colleagues identify a noncoding RNA that is upregulated in the brains of individuals with Alzheimer's disase. This noncoding RNA increases expression of BACE, driving amy...