Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine

• Published in: The Journal of biological chemistry Vol. 295; no. 30; pp. 10493 - 10505
• Main Authors: Singhal, Rashi, Shah, Yatrik M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.07.2020; American Society for Biochemistry and Molecular Biology
• Subjects: Adaptive Immunity; Animals; Basic Helix-Loop-Helix Transcription Factors - immunology; colitis; colon cancer; Colorectal Neoplasms - blood supply; Colorectal Neoplasms - immunology; Colorectal Neoplasms - microbiology; Colorectal Neoplasms - pathology; Gastrointestinal Microbiome - immunology; HIF-2α; Humans; hypoxia; Hypoxia - immunology; Hypoxia - microbiology; Hypoxia - pathology; hypoxia-inducible factor (HIF); hypoxia-inducible factor 1α (HIF-1α); Immunity, Innate; inflammation; Inflammation - immunology; Inflammation - microbiology; Inflammation - pathology; inflammatory bowel disease (IBD); intestinal epithelium; intestinal metabolism; Intestinal Mucosa - blood supply; Intestinal Mucosa - immunology; Intestinal Mucosa - microbiology; Intestinal Mucosa - pathology; iron; iron metabolism; JBC Reviews; mucosal barrier; Oxygen - immunology; hypoxia; colitis; HIF-2α; colon cancer; inflammatory bowel disease (IBD); hypoxia-inducible factor 1α (HIF-1α); iron metabolism; hypoxia-inducible factor (HIF); mucosal barrier; inflammation; iron; intestinal epithelium; intestinal metabolism

The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also harbors a large and diverse microbial population collectively called the gut microbiome (microbiota). The microbiome–intestine cross-talk includes a dynamic exchange of gaseous signaling mediators genera...