Lysophospholipids Facilitate COPII Vesicle Formation

• Published in: Current biology Vol. 28; no. 12; pp. 1950 - 1958.e6
• Main Authors: Melero, Alejandro, Chiaruttini, Nicolas, Karashima, Takefumi, Riezman, Isabelle, Funato, Kouichi, Barlowe, Charles, Riezman, Howard, Roux, Aurélien
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 18.06.2018; Cell Press
• Subjects: budding assays; COP-Coated Vesicles - metabolism; COPII; lysolipids; Lysophospholipids - genetics; Lysophospholipids - metabolism; membrane curvature; membrane rigidity; Microsomes - metabolism; phospholipase; Saccharomyces cerevisiae - metabolism; vesicular transport; budding assays; phospholipase; COPII; membrane curvature; membrane rigidity; lysolipids; vesicular transport

Coat protein complex II (COPII) proteins form vesicles from the endoplasmic reticulum to export cargo molecules to the Golgi apparatus. Among the many proteins involved in this process, Sec12 is a key regulator, functioning as the guanosine diphosphate (GDP) exchange factor for Sar1p, the small guan...